Petersen E., Jaruga P., Dizdaroglu M., Nelson B.
National Institute of Standards and Technology, US
Keywords: mass spectrometry, nano-EH&S, nanogentoxoicity, nanoparticles
Hyphenated mass spectrometry (gas chromatography/mass spectrometry) techniques have been employed as one of the primary analytical tools for investigating the effects of ionizing radiation, chemical/biological carcinogens and oxygen derived free radicals on the induction and subsequent repair of oxidatively-induced DNA damage (DNA lesions) in living systems. Certain DNA lesions, such as 7,8-dihydro-8-oxoguanine (8-OH-Gua), are not only established mutagens, but have also been utilized as biomarkers of systemic oxidative stress. The National Institute of Standards and Technology (NIST) has established a comprehensive research program focused on identifying and characterizing the DNA damaging mechanisms of commercially relevant engineered engineered nanoparticles (NPs) using models of increasing biological complexity through the application of isotope-dilution hyphenated mass spectrometry tools for the quantification of oxidatively-induced DNA damage. We present an overview of our recent findings from studies on metal (AuNP and AgNP), metal oxide (CuO NP), and carbon-based (SWCNTs and MWCNTs) nanoparticles.
Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2014: Electronics, Manufacturing, Environment, Energy & Water
Published: June 15, 2014
Pages: 142 - 145
Industry sectors: Advanced Materials & Manufacturing | Energy & Sustainability
Topics: Advanced Manufacturing, Environmental Health & Safety of Nanomaterials
ISBN: 978-1-4822-5830-1