Biosensing, Diagnostics & Imaging

Nanostructured Memristor Sensor Mimics Acetylcholinesterase (ACHE) Active Sites in the Gorge for fM Detection of Acetylcholine

Chen E.T., Thornton J., Ngatchouand C., Duh S-H, Advanced Biomimetic Sensors, Inc., US

Many diseases including cancer, diabetes, brain injury, epilepsy, Parkinson’s, autism and Alzheimer’s involve the up regulation of acetylcholinesterase (ACHE) inappropriately signaling of cholinergic synapse for an excess production of the neurotransmitter acetylcholine (ACH). Challenges for [...]

Ultrasensitive and rapid immuno-detection of bacteria and protein biomarkers using field-effect enzymatic detection

Yau S.-T., Cleveland State University, US

A novel immuno-detection system has been constructed by incorporating the newly invented field-effect enzymatic detection (FEED) technique the immunosensing technique to demonstrate a novel detection platform. The demonstration consists of the detections of three biomarkers [...]

EXIRM: A Novel Technique for Label-Free Detection of MicroRNA

Wang Y., Xu S., University of Houston, US

MicroRNAs play important roles in cancer and other diseases. However, due to the transient nature of the MicroRNAs, it remains challenging to achieve high sensitivity and accuracy to quantify MicroRNAs. We are developing a new [...]

Synthetic LNA/DNA Nano-scaffolds for Highly Efficient Diagnostics of Nucleic Acids and Autoimmune Antibodies

Astakhova I.K., University of Southern Denmark, DK

Herein we describe fluorescent oligonucleotides prepared by click chemistry between novel alkyne-modified locked nucleic acid (LNA) strands and a series of fluorescent azides for highly efficient homogeneous (all-in-solution) detection of nucleic acids and autoimmune antibodies. [...]

Real-time monitoring of pathogens and nanomarkers in water by resonance laser spectroscopy techniques

Moguilnaya T.Yu., Bobkov P.V., Tomilin V.A., Kononenko E.B., JSC “SERVET-M”, RU

We develop a new method, allowing real-time monitoring of pathogens and DNA in water. The method is based on an analysis of radiation spectra in near-IR region. We have applied this method for rapid analysis [...]

Detection of Prostate-Specific Antigen (PSA) with an Ultra High Performance Electrode Modified with Sol-Gel Au Nanoparticles

Leung S.W., Mozneb S., Lai J.C.K., Assan D., Idaho State University, US

Prostate cancer is one of the leading cancer causing death in men, especially in western developed countries. Prostate-specific antigen (PSA) is one of the biomarker that can be used to diagnose prostate cancer, although using [...]

Fabrication of Aptamer-Functionalized Gold Nanorod Biosensor for Colorimetric Detection of Lysozyme

Tohidi Moghadam T., Ranjbar B., Tarbiat Modares University, IR

Gold nanorods (GNRs) have been nominated as good candidates for biosensing, diagnostics, and imaging technologies. The wavelength dependence of the longitudinal surface plasmon resonance of gold nanorods on minute changes of refractive indexes makes them [...]

Multimodal Nano-Brain-Machine-Interface for Parallel Electrochemical NeuroSignal Sensing

Poustinchi M., Stacey G., Musallam S., McGill University, Neural Prosthetics Laboratory, CA

Thanks to technological advancements in recent decades, outstanding progress has been made in the field of neuroscience and neural engineering. Although the information processing in the brain is mostly done through neuron’s electrical activities, there [...]

Nanostructured Biomimetic Memristor Sensors Used for Therapeutic Monitoring of the Brain Cancer

Chen E.T., Thornton J., Ngatchou C., Duh S-H, Kissinger P.T., Advanced Biomimetic Sensors, Inc., US

Current technology is not available to provide a portable, simple and accurate real-time monitoring and treatment of cancers simultaneously in an early stage at a clinical setting. Challenges for developing such a tool, include the [...]

Resistance and Potentiostatic Based Measurements of an Antibody Functionalized Conductive Polymer Coated Textile as a Biosensor

Bandremer A., Hebert A., Torosian S.D., Battacharyya D., Gleason K., McGraw S.K., Senecal A., Marek P., Food and Drug Administration, US

Effective food safety monitoring is challenged by the necessity to identify human infection capable microorganisms at sufficient infective doses and consumption levels. Regulatory agencies have developed methods for assessing food safety based on currently available [...]

Carcinogenicity Assessment Using Biosensors: Mitomycin-C As A Case Study

Alhadrami H.A., King Abdulaziz University, SA

This study enabled an empirical assessment of a model carcinogen borne in soil and its potency on human receptors. SOS-lux biosensors had numerous practical advantages over the traditional assays including procedural simplicity, ease of measurement [...]

DETECHIP®: Developing a Molecular Sensing Device

Okuom M.O., Holmes A.E., Doane College, US

DETECHIP® is a detection system made of various sensors that has been shown to detect and discriminate between small molecules of interest, including various illicit drugs for and over-the-counter medications, explosives, pesticides and food spoilage [...]

Novel silicon microdosimeter based on 3D cylindrical structures

Guardiola C., Carabe-Fernández A., Gomez F., Pellegrini G., Fleta C., Quirion D., Lozano M., University of Pennsylvania, US

A new design of a solid-state-detector based on silicon microfabrication is provided in this work in order to create a novel microdosimeter. This microdosimeter improves the performance of existing microdosimeters using three-dimensional microfabrication technology development. [...]

Electrochemical Detection of Alcohol using Enzyme Sensor with Chromatography Paper and its Potential Application as halal Sensor

Musa M.S., Kuretake T., Harada Y., Hori F., Uno S., Ritsumeikan University, JP

The Islamic law forbids Muslims from consuming food that contains porcine derivatives and alcohol, among others. The halal term is not limited to only the food ingredients but also considers the absence of non-halal species [...]

A CMOS Lab-On-A-Chip For Neuron Monitoring And Stimulation

Ghallab Y.H., Ismail Y., Center of Nano Electronics and Devices (CND) at American University in Cairo/ Zewail City of Science and Technology, Cairo, Egypt, EG

Many tools have been established to monitor neural activity such as patch pipettes and microelectrodes, which are electrolyte filled glass tubes used to create intracellular contacts by rupturing the cell membrane and directly measuring the [...]

Papers: