Authors: I. Ben Slama, S. Amara, N. Rihane Ben Younes, I. Mrad, K. Omri, J. El Ghoul, L. El Mir, K. Ben Rhouma, H. Abdelmelek, M. Sakly
Affilation: Faculty of Sciences, Tunisia
Pages: 365 - 368
Keywords: ZnO nanoparticles, ZnCl2 , liver, kidney, rats
Recent studies have shown that Zn2+ is released from the surface of ZnO NPs when they are suspended in an aqueous state.The aim of this study was to evaluate the effects of ZnO nanoparticles (ZnO-NPS) and ZnCl2 in solution on plasmatic biochemical parameters, tissues trace elements and their possible cytotoxicity in rat liver and kidney. Rats were treated orally with doses of (ZnO-NPs) or (ZnCl2) (10 mg/Kg) for 5 consecutive days,control group received a dose of 0.9℅ sodium chloride. Sub-acute exposure to ZnO-NPs or ZnCl2 showed no significant change either in body weight, kidneys and liver weight. Oral administration of ZnO-NPs or ZnCl2 increased the plasmatic transaminase activity (AST and ALT). However, the creatinine, uric acid and blood glucose concentrations remained unchanged. Rats received ZnO-NPs or ZnCl2 solution showed a no significant increase of zinc content in the liver and kidney. Morover, the concentration of trace elements were slightly modulated after ZnO-NPs or ZnCl2 exposure. Histological analysis in the liver and kidney showed signs of discreet cytotoxicity (Inflammatory response, Vascular congestion, edema formation) in ZnO-NPs and ZnCl2 treated-rats compared to control group. Oral administration of ZnO-NPs or ZnCl2 showed no obvious toxic effect in rat liver and kidney.