Nanotech 2013 Vol. 3
Nanotech 2013 Vol. 3
Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy (Volume 3)

Materials for Drug & Gene Delivery Chapter 3

Thermosensitive Vaginal Gel Containing PLGA-NTRI Conjugate Nanoparticles for HIV Prophylaxis

Authors: A. Rajca, Q. Li, A. Date, C. Destache

Affilation: Creighton University School of Pharmacy & Health Professions, United States

Pages: 293 - 296

Keywords: NRTI conjugate, thermosensitive gel, HIV prophylaxis

A critical component to the prevention of the sexual transmission of HIV is adherence to the prevention modality. We have conjugated nucleoside-reverse transcriptase inhibitors (NRTIs) to a biocompatible polymer, PLGA using an amide bond. We have then taken this conjugated product and fabricated NRTI nanoparticles (NPs) as a sustained-release system. Furthermore, we have incorporated the NRTI-conjugated NPs into a thermosensitive gel to deliver the NPs vaginally as a prevention modality. Preliminary data is presented in the abstract.

ISBN: 978-1-4822-0586-2
Pages: 806
Hardcopy: $209.95

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