Vismara E., Torri G., Valerio A., Graziani G., Montanelli A., Melone L.
Politecnico di Milano, IT
Keywords: cellulose glycidylmethacrylate infections antibiotics
Abstract: In this work we report how cotton fibers can be easily functionalized with glycidylmethacrylate (GMA) by means of the Fenton’s reaction and used for the manufacturing of biomedical textiles having significant capability to adsorb amoxicillin and vancomycin, two different antibiotics largely used in the clinical activity. The reversible adsorption capacity can be modulated by simple chemical treatments after the grafting of GMA on the cellulose backbone, through the epoxy ring opening by addition of water molecules or primary diamines having different aliphatic chain length (2 to 6 C atoms). The pristine cellulose fibers have no any adsorption capability. Such materials can find suitable application as wounds dressing or more in general for the topical administration of drugs.
Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2012: Bio Sensors, Instruments, Medical, Environment and Energy (Volume 3)
Published: June 18, 2012
Pages: 174 - 177
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech
Topics: Biomaterials, Materials for Drug & Gene Delivery
ISBN: 978-1-4665-6276-9