Authors: C. Mattu, S. Sartori, E. Ranzato, M. Boffito, R. Li and G. Ciardelli
Affilation: Politecnico di Torino, Italy
Pages: 314 - 317
Keywords: nanoparticles, polyurethanes, polyesters, Paclitaxel
Biodegradable polymeric micro and nanoparticles have shown to be promising forms for the delivery of a wide array of drug formulations, such as hydrophobic or hydrophilic active principles, proteins or other bio molecules. The aim of this study was to prepare micro and nanospheres starting from commercial polyesters, such as Poly-ε-Caprolactone (PCL) and Poly Lactic Acid (PLA) or proprietary polyester-urethanes (PU), for the controlled and targeted delivery of the anticancer drug Paclitaxel (PX) which has proved high efficacy against different tumours.