Authors: K. Madhavan, D. Belchenko, W. Tan
Affilation: University of Colorado at Boulder, United States
Pages: 329 - 332
Keywords: collagen, genipin, viscoelasticity, biocompatibility, smooth muscle cell
This study involves the mechanical and biological characterization of crosslinked collagen-based scaffolds for arterial medial-equivalent. These scaffolds are made from a mixture of collagen, chitosan and elastin and crosslinked with genipin. The method of optimization of mechanical and biological properties involves the variation of concentration of components (collagen & chitosan) and crosslinker (genipin). Varying the concentration improves the biomimetic mechanical properties. Even though smooth muscle cells and endothelial cells exhibit high biocompatibility to genipin-crosslinked scaffolds, varying the genipin concentration affects the cell ingrowth in these scaffolds. By striking a balance between the mechanical and biological properties, we are able to design a suitable material.