Cancer Nanotechnology – TechConnect Briefs

Radiolabeling of Nanoshells with Cu-64 and In-111 for PET and SPECT Imaging in Rats

Xie H., Wang Z., Bao A., Goins B., Phillips W.T., Coleman C.L., Texas Southern University, US

Here we report for the first time the radioactive labeling of gold-silica nanoshells with Cu-64 and In-111. A bifunctional polyethylene glycol (PEG2000) is used as crosslinker to connect nanoshells with DOTA or DTPA, which are [...]

Treatment of Breast Cancer with Silver Antitumor Drugs Encapsulated in Biodegradable Polymeric Nanoparticles

Youngs J., Youngs W.J., Robishaw N., Panzner M.J., Hindi K., Medvetz D.A., Youngs J., Youngs W.J., Tessier C., Ditto A., Yun Y.H., Bauer J., Lindner D., University of Akron, US

Our research in cancer focuses on the development of silver carbene complexes (SCCs), for use as antitumor agents. We have found that SCCs have significant activity against a variety of cancers in vitro. Furthermore SCCs [...]

Intrinsic oxidase activity of cerium oxide nanoparticles facilitate the detection of cancer biomarkers and cancer cells

Perez J.M., Asati A., Santra S., Kaittanis C., Nath S., University of Central Florida, US

Nanomaterials exhibit unique size-dependent physical properties. Thus, identifying novel properties of these materials at the nanoscale, and their applications in energy, catalysis and medicine, among others, is an area of current and intense research. Cerium [...]

Enhancement of Photocatalytic Cancer Cell-Killing Activity by Using Ag@TiO2 Core-Shell Composite Nanoclusters

Abdulla-Al-Mamun M., Yang H., Kusumoto Y., Kagoshima University, JP

The photocatalytic cancer cell-killing activities of the Ag@TiO2 core-shell composite colloidal nanoclusters have been investigated on HeLa cells killing under the UV-visible light irradiation. The Ag metal core-TiO2 shell (Ag@TiO2) composite nanocluster photocatalyst with uniform [...]

Contrasting agent for magnetic resonance imaging based on nanostructural dispersion of Manganese derivative of phthalocyanine: preliminary investigation results

Meerovich G.A., Meerovich I.G., Meerovich G.A., Meerovich I.G., Dolotova O.V., Uchevatkin A.A., Yu. Saveliev O., Yu.Baryshnikov A., Andronova N.V., Oborotova N.A., Kaliya O.L., Pirogov Yu.A., Vorozhtsov G.N., Yu.Baryshnikov A., N.N. Blokhin Russian Cancer Research Center or RAMS, RU

Contrast agents (CA) are used to increase tumor contrasting in magnetic resonance imaging (MRI). The work is devoted to estimation of Manganese chloride tetra-3-phenylthio-tetra-5-tert-buthylphthalocyanine [3-(PhS)4-5-(t-Bu)4PcMnCl] as potential CA for MRI. We have developed the micellar [...]

Atomic Force Microscopy as a Tool for Research in Oncocytology

Reshetov I.V., Chissov V.I., Volchenco N.N., Sukharev S.S., Slavnova E.N., Ivanov Yu.S., P.A.Hertzen Moscow Research Oncological Institute (MROI), RU

Most of investigations have studied specimens prepared by complex techniques which are unusual for hospitals. In present paper Scanning Probe Microscopy (SPM) has been used for searching signs of malignancy in specimens prepared identically to [...]

Nanotube Biosensor Arrays for Detection of Molecular Surface Markers in Breast Cancer Cells

Panchapakesan B., Wickstrom E., University of Louisville, US

Recent reports have shown that nanoscale electronic devices can be used to detect a change in electrical properties when receptor proteins bind to their corresponding antibodies functionalized on the surface of the device, in extracts [...]

The development of multicolor panels with Quantum Dots-conjugated antibodies for diagnostics of Chronic Lymphoid Leukemia (CLL) by conventional flow cytometer

Barteneva N., Vorobjev I., Harvard Medical School, US

Diagnostics of leukemia and lymphomas by flow cytometry emerged in 90-th years of last century when several consensus panels had been introduced and based on three-four color cytometry. The standard flow diagnostics approach requires 10-15 [...]

Role of Ultrasound in Anti-Cancer Drug Delivery Loaded on Microspheres

Mohamed M.M., El belbese M.A., Kotb M.A., Fikry N.M., Ramadan H.S., Alexandria University, EG

Targeting is a new therapeutic tool for malignant tumor as a result of combining nanotechnology with chemotherapeutics. Ultrasound has been shown to enhance degradation and drug delivery from biodegradable and non biodegradable polymeric devices. If [...]

Preliminary studies of new photosensitizer for photodynamic treatment of melanoma based on nanostructural forms of Bacteriochlorin p N-alkoxycycloimide alkoxyoxyme methyl ester

Meerovich G.A., Meerovich I.G., Meerovich G.A., Meerovich I.G., Grin M.A., Pozdeyev V.I., Tsiprovskij A.G., Oborotova N.A., Loschenov V.B., Yu.Baryshnikov A., Mironov A.F., A.M. Prokhorov General Physics Institute of RAS, RU

This work is devoted to investigation of Bacteriochlorin p N-alkoxycycloimide alkoxyoxyme methyl ester which possesses its absorption band at 795-800 nm. We have estimated the applicability of PDT with this photosensitizer to treat melanoma. We [...]

Epirubicin hydrochloride loaded poly (butyl cyanoacrylate) nanoparticles: formulation optimization, characterization and in vitro evaluation on human breast cancer cell lines

Dantuluri P.R., Shah N.M., Murthy R.S.R., Kumar M.R.S., Rao B.S.S., The M.S. University of Baroda, IN

Breast cancer is the second leading cause of deaths in women today after lung cancer, the mortality rate of patients with breast cancer around the world is rising steadily over time. Metastatic spread is the [...]

Anticancer Iron Oxide Nanoparticles

Benyettou F., Lalatonne Y., Sainte-Catherine O., Lecouvey M., Motte L., Laboratoire CSPBAT FRE 3043 CNRS, FR

We designed a new therapeutic nanoplatform which could be both imaged in situ with MRI (T2 contrast agent) and/or addressed by magnetic targeting (magnet) or specific molecules (peptides, antibodies …). The biological in-vitro tests performed [...]

PMMA/SWCNTs Composites for Prostate Brachytherapy MRI Contrast Agent Markers

Martirosyan K.S., Stafford R.J., Elliott A.M., Frank S.J., University of Houston, US

Prostate brachytherapy (PB) is an alternative to traditional external beam radiation or surgery for men who have prostate cancer. PB used implanted radioactive titanium seeds and has increased in popularity over recent years due to [...]

Method of LANTCET for cancer diagnostics and treatment at cell level

Hleb E.Y., Zastinskaya I.A., Ilyukova I.I., Semenenya I.N., Hafner J.H., Hanna E.Y., Myers J.N., Zhdanok S.A., Lapotko D.O., A. V. Lykov Heat & Mass Transfer Institute, BY

We have developed the method of LANTCET (laser-activated nano-thermolysis as a cell elimination technology) for selective detection and destruction of individual tumor cells by generating intracellular photothermal bubbles around the clusters of gold nanoparticles. Bare [...]

Carbon Nanotubes as Molecular Nanocarriers for Antibody Delivery and Photothermal Ablation of Breast Cancer Cells

Panchapakesan B., Wickstrom E., University of Louisville, US

In this paper, the utilization of carbon nanotubes as nanocarriers for antibody delivery to IGF1R and HER2 surface receptors and selective thermal ablation of breast cancer cells is presented. IGF1R and Her2 surface receptors are [...]

Use of PBMC Partitioning to Predict RES-Uptake of a Nanoemulsion in a Colon Cancer Xenograft

Devalapally H., Clogston J.D., Amiji M.M., McNeil S., Stern S.T., SAIC-Frederick, National Cancer Institute at Frederick, US

Nanotechnology platforms have emerged as versatile carrier systems for delivery of active molecules to tumors. Nanoparticle-based formulations have demonstrated enhanced efficacy and decreased toxicity in comparison to conventional drugs. These carrier systems often encounter rapid [...]

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