Authors: M. Larabi, M. Mackanos, R. Shinde, C. Contag, S. Guccione
Affilation: Stanford University, United States
Pages: 484 - 486
Keywords: liposome, thermoablation, imaging, ultrasound, tumor, in vivo, luciferin, thermosensitive
Local delivery of therapeutic drugs will increase drug concentration at the site of treatment for maximum efficacy, and reduce systemic drug exposure. The encouraging results obtain in first phase of the clinical study of doxorubicin temperature sensitive liposome open a new way for the early cancer therapy. These heat sensitive liposomes accumulate in the RES organs can be used to deliver chemotherapy locally by using focus ultrasound. Additionally, through specific molecular targeting, we can bind these liposomes to other sites of disease for local drug delivery. As an initial evaluation, luciferin was encapsulated in the liposome to provided release characteristics after heating. We have developed temperature sensitive stable liposomes that release their drug content upon local heating. Different formulations have given very encouraging results of the stability and of release profile upon heating in vitro in serum. After, the encouraging results have been obtained in vivo preliminary studies. The long-term goal of this project is to use focused ultrasound to heat and release chemotherapy to tumor lesions using targeted, heat-sensitive liposomes.