Nanotech 2008 Vol. 2
Nanotech 2008 Vol. 2
Nanotechnology 2008: Life Sciences, Medicine & Bio Materials - Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, Volume 2

Drug & Gene Delivery Systems Chapter 4

Preparation And Evaluation Of In Vitro Release Of Amphiphilic _-Cyclodextrin Or Pla Nanospheres Containing A Hydrophobic Drug

Authors: S. Lin, M. Lahiani-Skiba, N. Naouli, M. Skiba

Affilation: Université de Rouen, France

Pages: 411 - 414

Keywords: mebendazole, amphiphilic-cyclodextrin, PLA, nanospheres

Mebendazole (MBZ) is an antihelmintic which belongs to group of benzimidazols. It is used for many intestinal diseases and for other diseases. But its low absorption, its high dosages caused side effects on gastro-intestinal track, which limits its usage. In the present work, new colloidal drug carriers such as nanospheres are used in order to increase its solubility. As a consequence, the plasmatic concentrations of MBZ would increase, and the MBZ dosage could be reduced. Chemically modified cyclodextrins are amphiphilic, they can form colloidal suspensions where some drugs (water soluble or not) can be inserted

ISBN: 978-1-4200-8504-4
Pages: 808
Hardcopy: $159.95

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