Nanotech 2008 Vol. 2
Nanotech 2008 Vol. 2
Nanotechnology 2008: Life Sciences, Medicine & Bio Materials - Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, Volume 2

Drug & Gene Delivery Systems Chapter 4

Influence of water-soluble polymers and surfactants, on mebendazole solubilization by _- and permethyl-_-cyclodextrins

Authors: O-M. Ba, M. Lahiani-Skiba, S. Joudieh, F. Bounoure, M. Skiba

Affilation: Université de Rouen, France

Pages: 386 - 389

Keywords: water-soluble polymers, surfactants, Cyclodextrins

The objective of this work was to determine the influence of pH, water-soluble polymers and surfactants on mebendazole solubilization by beta- and permethyl-beta-cyclodextrins (beta-CD and PM-beta-CD). Mebendazole is an antihelmintic active drug used against a variety of intestinal parasites and potentially active against extra-intestinal parasitic infections. However, its low solubility renders it difficult to use. Cyclodextrins (CD) are able to increase the apparent solubility of poorly water-soluble active drugs by forming complexes

ISBN: 978-1-4200-8504-4
Pages: 808
Hardcopy: $159.95

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