Authors: R.M. van Dam, A.M. Elizarov, E. Ball, C.K-F Shen, H. Kolb, J. Rolland, L. Diener, D. Williams, B. Edgecombe, T. Stephen and J.R. Heath
Affilation: Siemens Molecular Imaging Biomarker Research, United States
Pages: 300 - 303
Keywords: microfluidics, radiopharmaceuticals, PET, FDG, synthesis, radiolabeling, world-to-chip interface
We present a fully-automated microfluidic system for the multi-step chemical synthesis of radiopharmaceuticals such as radiolabeled probes for positron emission tomography (PET). In earlier work, we developed a proof-of-principle PDMS microfluidic chip with a coin-shaped reactor, and have demonstrated the synthesis of 18FDG (2-[18F]fluoro-2-deoxy-D-glucose) on a scale and of quality sufficient for in vivo imaging in mice and rats. In order to produce FDG in amounts suitable for imaging at the human scale, we completely redesigned the chip architecture and operation. The latest generation chip and a novel fluidic adapter were integrated into a full functioning prototype instrument, consisting of reagent and product vials, ion exchange column, valves, reactor temperature controller, and vacuum system. All hardware was connected to a PC104-based controller and FDG synthesis was automated by software written in FIX32. This instrument would be suitable for the automated synthesis of biomarkers in a clinical setting or in a research environment for the development of new PET probes.
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