Authors: S.H. Kim and T.G. Park
Affilation: Korea Advanced Institute of Science and Technology, Korea
Pages: 770 - 771
Keywords: VEGF, siRNA, polyelectrolyte complex micelle, cancer gene therapy
We developed a polyelectrolyte complex (PEC) micelle-based delivery system for treatment of prostate cancer. A PEGylated siRNA targeting human vascular endothelial growth factor (hVEGF) was synthesized. The hVEGF expression was almost completely inhibited in vitro as well as in vivo by treating cancer cells with PEC micelles formed from the interaction between the conjugate and polyethylenimine (PEI). The efficient hVEGF gene silencing by hVEGF siRNA-PEG/PEI complexes dramatically suppressed tumor neovasculization and tumor growth in animals with PC-3 tumor xenograft.
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