Authors: D.A. Gish, F. Nsiah, M.T. McDermott and M.J. Brett
Affilation: University of Alberta, Canada
Pages: 461 - 464
Keywords: localized surface plasmon resonance, glancing angle deposition, biosensor, silver nanostructures
The localized surface plasmon resonance (LSPR) biosensing capability of 175 nm thick silver nanoparticle films produced by glancing angle deposition (GLAD) was evaluated. The extinction spectra of the films exhibited a peak around a wavelength of 369 nm which was observed to red-shift linearly with increasing refractive index of the surrounding medium. The films were functionalized with solutions of 11-amino-1-undecanethiol, hydrochloride and rabbit immunoglobulin G (IgG) to allow for the detection of anti-rabbit IgG binding. Binding of biomolecules to the nanoparticle surface increases the local refractive index and results in a red-shifting of the extinction peak. The wavelength shift at varying concentrations of anti-rabbit IgG was measured and fit to the Langmuir isotherm.
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