Papers:
Fluorescent Structural DNA Nanoparticles Functionalized With Phosphate-Linked Nucleotide Triphosphates
Structural DNA nanoparticles functionalized with phosphate-linked nucleotide triphosphates (dNTPs) were tested as a source of dNTPs for DNA polymerase. The particles were prepared by strand-displacement polymerization from a self-complementary circular template. An intercalating dye (SYBR-101) [...]
In Situ Investigation of Uptake Phenomena of Biological Molecules and Silica Nanoparticles into Mammalian Cells in Microstructures
Lee W.G., Bang H., Yun H., Kim J.A., Cho K., Shin Y.S., Chung C., Chung N.C., Chung C., Chung N.C., Chang J.K., Han D-C, Seoul National University, KR
Electroporation is a powerful gene transfection method to deliver foreign biological molecules such as DNA and protein into living cells with electric pulsations. However, conventional cuvette-type electroporation techniques generally suffer from poor transfection efficiency and [...]
Synthesis, Encapsulation and Functionization of Composite Organic-Inorganic Nanoparticles with Distinctive Surface Enhanced Raman Signatures
Zhang J., Lu Y., Lutz B., Cao M., Qin H., Yamakawa M., Dentinger C., Nguyen L., Chmura A.J., Zhu J., Lutz B., Sung K-B, Swartz K., Wang L., Su X., Sun L., Sung K-B, Berlin A.A., Chan S., Sun L., Sung K-B, Intel Corporation, US
Composite organic-inorganic nanoparticle (COIN) is a new type of optical label for multiplex biomolecule detection. It has strong Raman signal intensity and potentials for a large number of unique Raman signatures. We have developed methods [...]
In vivo imaging by luminescent carbon nanotubes
There is currently an increasing need for early detection of cancer before anatomic anomalies are visible. A major challenge in cancer diagnosis is to be able to locally biomark the cancer cells in clinical pathology [...]
Application of Quantum dots for the lifespan study of Caenorhabditis elegans
The progress in identifying drugs that extend lifespan of Caenorhabditis elegans has been slow partly due to the tedious and labor-intensive nature of drug screening. We labeled C. elegans by mixing quantum dots, FITC, or [...]
Quantum Dots for Multimodal Bioimaging and Sensing Applications
Santra S., Yang H., Sabui S.K., Sharma P., Holloway P.H., Walter G.A., Moudgil B.M., Scott E., University of Central Florida, US
Fluorescent quantum dots (Qdots) have demonstrated their potential in diagnostic bioimaging applications in vitro. For in vivo bioimaging applications, however, the embodiment of additional properties such as paramagnetism onto the same fluorescent probes is highly [...]
A pbpk model to elucidate processes governing distribution and excretion of polyacrylamide nanoparticles
This paper presents a physiologically based pharmacokinetics model that has been calibrated using experimental measurements of biodistribution and excretion of polyacrylamide nanoparticles in rats. The model is capable of establishing the complete mass balance of [...]
Single Base Mismatch Determination using DNA – Silver Nanoparticle Conjugates
Modification of oligonucleotides with gold nanoparticles was first reported ten years ago and opened up several new avenues of research as they can be used as a novel nanostructured building material but the conjugate can [...]
A Fluorescence Spectroscopy Study on the Encapsulation of Hydrophobic Dyes in Core-Shell Nanoparticles
Novel core-shell nanoparticles were prepared as encapsulating agents for fluorescent organic dyes. These particles protect the dyes from polar solvents, allowing their use in aqueous environments, such as biological systems. The nanoparticles were synthesized using [...]
Fluorescent Nanoparticles Based on Chitosan
Chitosan is a basic linear polysaccharide containing β-[1→4]-linked 2-acetamido-2-deoxy-D-glucopyranose and 2-amino-2-deoxy-D-glucopyranose units. Because of the presence of reactive amino groups, chitosan can be modified easily to create nano- and micro particulate systems, films or porous [...]
The Potential use of Fluorescent Nanoparticles from Hydrothermal Synthesis in Cell Imaging
We are using self fluorescing nanoparticles from a nozzle continuous hydrothermal synthesis reactor cell signalling. Most established methods for producing nanoparticles involve relatively noxious chemicals, have a complex and time-consuming sequence of stages, or may [...]
Creation of an Aptamer Nanobiosensor for Ultra-Sensitive Detection of Heart Failure
This project focuses on discovering a new aptamer sequence that binds specifically and with high affinity to Brain Natriuretic Peptide (BNP), which is indicative of the early stages of heart failure. A library of random [...]
Design of Magnetic Nanoparticles for Purification of His-tagged Recombinant Proteins
Manipulation of proteins effectively for in-vitro study is an important step of research in the area of proteomics. The expression of recombinant proteins with histidine fusion tags(6xHis) is widely used to ease their purification from [...]
Differential lethality of gold nanoparticles is associated with immunogenecity
To obtain antibodies specifically recognizing gold nanoparticles (GNPs) BALB/C mice were immunized by weekly intra-peritoneal injection of adjuvant-emulsified 5 nm, 8 nm, 12 nm, 17 nm, and 37 nm GNPs. Mice injected with 8 nm, [...]
Synthesis, Properties and Biomedical Applications of Novel Core-Shell Iron Magnetic Nanoparticles
Nanoparticles have gained increased attention recently for biomedical and environmental applications. Biocompatible magnetic nanoparticles (MNPs) have been found promising in several biomedical applications for tagging, imaging, drug delivery, sensing and separation in recent years. Most [...]
Heating efficiency of debundled carbon nanotubes compared to carbon black
This work examines the amount of heat generated by single-wall and multi-wall carbon nanotubes to show how bundling and adequate dispersion of the tubes effects heat generation. Due to their high aspect ratio, nanotubes behave [...]
Gold nanoshells aided optical imaging in vitro, in vivo and ex vivo
Lee M., Loo C., Gobin A.M., West J., Halas N., Drezek R., Korea Electronics Technology Institute, KR
Scattering-based optical imaging technologies such as Optical Coherence Tomography (OCT) and Reflectance Confocal Microscopy (RCM) offer a unique non-invasive approach to the detection, diagnosis, and monitoring of cancer. In this article, we describe the use [...]
Gatifloxacin Nanoparticles For Ophthalmic Delivery
Motwani S.K., Ahmad F.J., Iqbal Z., Talegaonkar S., Khar R.K., Faculty of Pharmacy, Hamdard University, IN
Biodegradable colloidal nanoparticles of Poly (lactide-co-glycolide) (PLGA) have received considerable attention as a possible means of delivering drugs because of their biocompatibility and resorbability through natural pathways. As the ocular efficacy of drugs is greatly [...]
Formation of Nano CoFe2O4 Crystallites in Hydroxyapatite
Embedding nano size CoFe2O4 ferrite particles in a hydroxyapatite (HAP) host would make them to better candidates for hyperthermia treatment of cancer. The formation of nano crystallites of CoFe2O4 ferrites in the hydroxyapatite Ca10-3xFe2xCox(PO4)6(OH)2 (where [...]
Mathematical model of drug delivery using Anti-cancerous Herbal drugs
Pharmacokinetics deals with the distribution of drugs, chemicals, tracers or radioactive substance among the various compartments of the human body. Compartment modeling is very convenient for biochemical transformation. In this paper, we have used basic [...]
Targeting Nanoparticles to Tumors using Adenoviral Vectors
Saini V., Enervold M.R., Perez A., Koploy A., Perkins G., Ellisman M.H., Green H.N., Mirov S.B., Zharov V.P., Everts M., University of Alabama at Birmingham, US
Despite advances in detection and treatment of cancer, development of novel therapies remains essential; in this regard, nanotechnology holds great promise. For example, tumor imaging opportunities have expanded by the development of quantum dots (QDs) [...]
Nano gold can drop PSA level
abstract Reaches first finding nano gold under 10 nm can improve micturition. We did several tests for one who has prostate cancer. We find one who has PSA level 193 with harmony treatment for several [...]
Shape-controlled synthesis and functionalization of gold nanoparticles for hyperthermia applications
Control of nanoparticle shape may initially seem like a scientific curiosity, but its goal goes far beyond aesthetic appeal. The shape not only influences the chemical and optical properties of metal nanoparticles, but also their [...]
Characterization of Nano- & Microparticles Suitable for Drug & Gene Delivery by Freeze-fracture Electron Microscopy
The potency of drug/gene-loaded nanoparticles is frequently depending upon their morphology adopted in a biological relevant environment. Freeze-fracture electron microscopy (ff-em) is a powerful techniques to monitor the self-assembling of lipid-, polymer-, as well as [...]
Optimisation of magnetoliposomes for biomedical multi-tasking; potential dual contrast agents and drug delivery vehicles
The relaxivity and particle size of both solid and aqueous-type magnetoliposomes are compared. The effect of magnetic filtration on the particle size and the size distribution is also examined. Our results suggest that magnetic filtration [...]
Chemical imaging using molecular spectroscopy – providing answers to fundamental biomedical questions at the nanoscale
HORIBA Jobin Yvon have been at the cutting edge of major breakthroughs in many key areas of instrument development and materials analysis including the latest hybrid approach of combining two or more techniques in one [...]
Nanoprobe for Optical Molecular Imaging
Optical molecular imaging (OMI) is a very powerful tool for studying the temporal and spatial dynamics of specific biomolecules and their interactions in real time in vivo. It exhibits the great advantages of high temporal [...]
An Investigation of Cellular Toxicity of Carbon Nanomaterials in African American Breast Cancer Cells
Functionalized CNTs and CNFs are attractive not only because they are theoretically easier to disperse in organic solvents and water, but also because there is some evidence that these modifications may enhance solubility and/or decrease [...]
Differential Uptake of PEG-Silica-FITC Nanoparticles by Human Breast Cancer Cells and Normal Human Breast Epithelial Cells
Iwakuma N., Sharma P., Delano M.J., Moldawer L.L., Moudgil B.M., Grobmyer S.R., University of Florida, US
Background: An understanding of uptake of nanoparticles (NPs) by human cancer cells and non-cancer cells is important for the development of NPs as novel cancer therapeutic and diagnostic agents. Hypothesis: Uptake of NPs is increased [...]
Delivery of Shiga Toxin 1 A Subunit into Epithelial Cells Using Silica-Based Nanowires
Kwon N.H., Beaux M., Sheng H., Ebert C., Wang L., McIlroy D.N., Hovde C.J., Bohach G.A., University of Idaho, US
Silica-based nanowires were used to introduce the Shiga toxin 1 A subunit (StxA1) into bovine and human epithelial cells. We extended our previous technology which employs fibronectin (Fn) as a ligand to induce integrin-mediated uptake [...]
Journal: TechConnect Briefs
Volume: 2, Technical Proceedings of the 2007 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: May 20, 2007
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech
Topics: Biomaterials, Materials Characterization & Imaging
ISBN: 1-4200-6183-6