Authors: L. Duncan, H. Shelmerdine, H.M. Coley and F.H. Labeed
Affilation: University of Surrey, United Kingdom
Pages: 45 - 48
Keywords: ion channel, blocker, conductivity, dielectrophoresis
Dielectrophoresis (DEP) is a phemomenon of induced particle motion in non-uniform electric fields. The effect is frequency dependent; by monitoring the motion of particles in AC fields and ananlysing the change in motion with frequency, it is possible to determine the electrical properties of single cells in lab-on-a-chip systems. In this paper we use DEP to study the electrical properties of drug-sensitive and drug-resistant cancer cells before and after treatment with channel blocking agents, which give insight into the origin of cytoplasmic differences shown to have a significant bearing on the origin of drug resistance in cancer.