Nanotech 2006 Vol. 1
Nanotech 2006 Vol. 1
Technical Proceedings of the 2006 NSTI Nanotechnology Conference and Trade Show, Volume 1

Nanoscale Structures and Devices Chapter 1

Cell Separation and Manipulation by magnetic field in the presence of functionalised magnetic nanowires

Authors: A. Prina-Mello, Z. Diao and J.M.D. Coey

Affilation: CRANN Research Laboratory, Ireland

Pages: 62 - 63

Keywords: magnetism, nanowires, cell separation, cell alignment,

In this paper we investigate the possibility of using magnetic nanowires in cell separation and manipulation. Ni, Co/Cr and Co/Fe nanowires made by electrochemical deposition in anodic aluminum oxide (AAO) templates. The combination between nanowires and different cells such as MC3T3 mouse fibroblasts, UMR-106 has been shown. There, cell viability with all the three kinds (Ni, Co/Cr and Co/Fe) of nanowires after combination was monitored. Magnetic cell separations were carried out following standardized conditions have achieved 75% purity and 75% yield. <br>Moreover, we were also successful in aligning the nanowires with cells in a 0.1 T uniform magnetic field. There, the axial of the magnetic nanowires internalised into cells can be aligned to the field direction with uniform magnetic field.<br>Therefore, a cell-nanowire interaction and living study will be addressed in the future in order to understand the intrinsic mechanisms responsible for cell internalization and alignment.

ISBN: 0-9767985-6-5
Pages: 871
Hardcopy: $119.95