Enhancement of E6 Protein Binding on Binding-Orientation-Sensitive Mixed SAMs Molecules

Tseng F-G, Tseng Y.T., Hwang J.K., Hung S.W., Chang J.M., Huang H.M., Huang T.W., Tseng F-G, Tseng Y.T., Huang H.M., Huang T.W., Chieng C-C
National Tsing Hua University, TW

Keywords: atomic force microscopy, binding, mixed SAMs, molecular dynamics simulation, protein

Orientation selectivity and binding enhancement with E6 protein are demonstrated by nano-structured mixed-SAMs systems of different chain lengths. Mixtures of n-alkinethiol SAMs of different chain lengths: 1-Decanethiol (C9) and 1-Hexanethiol (C5) are the examples in present work The demonstrations include the molecular dynamics simulations on the binding energies of a single E6 protein molecule with mixed SAMs molecules and the binding force measurements by Atomic Force Microscope (AFM) for a cluster of E6 protein molecules at different orientations with the same SAMs.

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Journal: TechConnect Briefs
Volume: 1, Technical Proceedings of the 2005 NSTI Nanotechnology Conference and Trade Show, Volume 1
Published: May 8, 2005
Pages: 442 - 445
Industry sectors: Medical & Biotech | Sensors, MEMS, Electronics
Topics: Biomaterials, Chemical, Physical & Bio-Sensors
ISBN: 0-9767985-0-6