Sun C., Veiseh O., Kohler N., Gunn J., Lee D., Sze R., Hallahan A., Zhang M.
University of Washington, US
Keywords: contrast agent, folic acid, iron oxide nanoparticles, magnetic resonance imaging, PEG, tumor imaging
Tumor specific superparamagnetic nanoparticle conjugates are currently being developed as targeting-contrast agents for magnetic resonance imaging (MRI). The application of such “smart” molecular imaging probes will have a significant clinical impact as a non-invasive method of cancer detection and diagnosis. In this study, we examine the vitamin folic acid (FA) as a targeting agent for the delivery of superparamagnetic nanoparticles to specific tumor cells in vitro. Results from this study suggest that the synthesized FA-superparamagnetic nanoparticle conjugates can be used to target specific tumor cells for detection by MRI.
Journal: TechConnect Briefs
Volume: 1, Technical Proceedings of the 2005 NSTI Nanotechnology Conference and Trade Show, Volume 1
Published: May 8, 2005
Pages: 74 - 77
Industry sector: Medical & Biotech
Topic: Biomaterials
ISBN: 0-9767985-0-6