Authors: C. Sun, O. Veiseh, N. Kohler, J. Gunn, D. Lee, R. Sze, A. Hallahan and M. Zhang
Affilation: University of Washington, United States
Pages: 74 - 77
Keywords: magnetic resonance imaging, contrast agent, iron oxide nanoparticles, PEG, folic acid, tumor imaging
Tumor specific superparamagnetic nanoparticle conjugates are currently being developed as targeting-contrast agents for magnetic resonance imaging (MRI). The application of such “smart” molecular imaging probes will have a significant clinical impact as a non-invasive method of cancer detection and diagnosis. In this study, we examine the vitamin folic acid (FA) as a targeting agent for the delivery of superparamagnetic nanoparticles to specific tumor cells in vitro. Results from this study suggest that the synthesized FA-superparamagnetic nanoparticle conjugates can be used to target specific tumor cells for detection by MRI.
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