Nanotech 2005 Vol. 1
Nanotech 2005 Vol. 1
Technical Proceedings of the 2005 NSTI Nanotechnology Conference and Trade Show, Volume 1

Medical Applications Chapter 2

Cellular Response to Nanoparticle Exposure

Authors: G.W. Erdos, D. Moraga, M. Palazuelos and K. Powers

Affilation: University of Florida, United States

Pages: 78 - 80

Keywords: toxicology,apoptosis,lysosomes,electron microscopy

Cells exposed to particles will phagocytose them and shuttle the endosomes to lysosomal compartments. Lysosomal mebranes rupture, possibly due to free radical formation. Proteases are released which inturn compromise the mitochondrial membranes. The mitochondria leak cytochrome-c which begins a process leading to apoptotic cell death.

ISBN: 0-9767985-0-6
Pages: 844
Hardcopy: $109.95

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