Papers:
Peptide Based Nanoparticles as a Platform for Vaccine Design
To-date vaccines for many of the dreadful diseases such as Tuberculosis, Malaria, AIDS and Hepatitis are still ineffective or unavailable. Peptide based vaccines have been developed but because of their poor immunogenic response and the [...]
Smart Bandage – A Hydrogel Supported Optical Microcavity Sensor
Developing new medical diagnostic technologies that can be used in the home for early detection and disease prevention is a central focus at the University of Rochester Center for Future Health. This paper is concerned [...]
Combinatorial Selection of Cell-Specific Peptides by Phage Display Experiments
We report for the first time the selection of novel peptides that are highly specific for endothelial progenitor cells (EPC) by screening phage display libraries. Our strategy for isolation of ligand peptides for cell surface [...]
Conical Tomograph: A Method for the Study of Macromolecular Assemblies
Zampighi G.A., Zampighi L., Fain N., Lanvazecchia S., Zampighi G.A., Zampighi L., University of California, Los Angeles School of Medicine, US
We have developed conical tomography to study the structure of macromolecular assemblies and organelles in their native cellular environment. Unlike the other related types of tomography, conical tomography has a higher throughput and more importantly, [...]
Loss of Elasticity of Ageing Epithelial Cells, and Its Possible Reversal
We investigated human epithelial cells of different age in-vitro by means of the atomic force microscopy. We found that older cells are considerably (~2-10 times) more rigid that younger cells. This helps to explain why [...]
Imaging Bio-electro-mechanics with Scanning Probe Microscopy: Unveiling Nature’s Nanoscale Form and Function
Jesse S., Baddorf A.P., Rodriguez B.J., Gruverman A., Kalinin S.V., Oak Ridge National Laboratory, US
A novel scanning probe technique for studying the physiological structure and electro-mechanical properties of nanoscale biological systems is discussed. The almost universal presence of piezo response in biological material makes this method applicable to a [...]
Apoptosis Characterization by Flouro-deoxy Glucose and Intracellular Sodium Distribution Using MicroPET/MRI in PC3 Induced Prostate Cancer in Mice Tumor
Background: Intracellular sodium (IC) and FDG accumulate in premalignant tumor sites. Hypothesis: High FDG and IC accumulation may characterize tumor stages. Objective: To develop rapid noninvasive hybrid microPET/MRI method to characterize PC3 tumor in mice. [...]
Intracellular Uptake of Folate Receptor Targeted Superparamagnetic Nanoparticles for Enhanced Tumor Detection by MRI
Sun C., Veiseh O., Kohler N., Gunn J., Lee D., Sze R., Hallahan A., Zhang M., University of Washington, US
Tumor specific superparamagnetic nanoparticle conjugates are currently being developed as targeting-contrast agents for magnetic resonance imaging (MRI). The application of such “smart” molecular imaging probes will have a significant clinical impact as a non-invasive method [...]
Cellular Response to Nanoparticle Exposure
Cells exposed to particles will phagocytose them and shuttle the endosomes to lysosomal compartments. Lysosomal mebranes rupture, possibly due to free radical formation. Proteases are released which inturn compromise the mitochondrial membranes. The mitochondria leak [...]
Nanomagnetic Immunoassay for Rapid Detection of Escherichia coli
This study identifies a simple process to quickly conduct an analysis, under field conditions, for detection of pathogens. A magnetic sandwich immunoassay is developed for rapid isolation and detection of targeted pathogen. Escherichia coli BL21 [...]
TMAZ Nanoparticles as Potential Drugs Influencing the Cellular Signal Transduction Pathways
Ivkovic S., Baranek T., Bendzko P., Schulz J., Klinomed Institut für Angewandte Nanotechnologie und Nanomedizin GmbH, DE
Currently, various antioxidants are under clinical investigation as an adjunct to standard and experimental cancer therapies. Anti-cancer activity of antioxidants may not only be attributed to their radical scavenger properties, but also to direct modulation [...]
Transient Analysis of Cooling of Biological Tissues Using Semi-Infinite Approximation
In the present paper, we have presented an analytical approach for transient analysis of cooling of biological tissues due to blood flow. Semi-infinite approximation for tissues is used and continuum approach is used for modeling.
Effect of Microtopography and Cell Concentration on T Lymphoid Cell Migration during in vitro Extravasation Process
The locomotion of leukocyte cells has been proved to be influenced by microtopographical patterns with and without surface chemistry [Prina-Mello et al., 2003, Lo et al., 2000]. In this study, parallel grooves were microfabricated on [...]
Static Magnetic Field Effects on Cells: A Possible Road to Cell Differentiation
The use of higher uniform magnetic field intensity, such as those used in magnetic resonance imaging, is thought to exert little influence at the cellular level. There are several experimental studies that indicate that magnetic [...]
Plasma-Treated and Collagen-Coated PLLA Nanofiber Membrane for Cartilage Tissue Engineering
Biodegradable nanofiber membranes from poly-L-lactic acid (PLLA) were prepared by electrospinning to be used as a scaffold in cartilage tissue engineering. Parameters during the electrospinning process were studied in detail in terms of diameters of [...]
Nanoelectronic CO2 Breath Sensors
The measurement of carbon dioxide levels in respiration is a standard of care or guideline according to the American Heart Association, the American Association of Respiratory Care, and the American Society of Anesthesiologists, and is [...]
Liquid Crystal Interactions with Nanostructure and Applications to Diagnostics and Medical Research
We will present data demonstrating the use of liquid crystal detection of protein in the development of rapid, label free diagnostics and assays. We control the orientation of liquid crystals by the fabrication of surfaces [...]
Journal: TechConnect Briefs
Volume: 1, Technical Proceedings of the 2005 NSTI Nanotechnology Conference and Trade Show, Volume 1
Published: May 8, 2005
Industry sector: Medical & Biotech
Topic: Biomaterials
ISBN: 0-9767985-0-6