Nanotech 2005 Vol. 1
Nanotech 2005 Vol. 1
Technical Proceedings of the 2005 NSTI Nanotechnology Conference and Trade Show, Volume 1

Microfluidics and Lab on Chip Chapter 11

The Manufacture and Preliminary Testing of a Novel Bio-MEMS Filtration Chip

Authors: P.T. Docker, M. Prince, P.K. Kinnell, M.C.L. Ward and X. Ma

Affilation: Birmingham University, United Kingdom

Pages: 692 - 695

Keywords: Bio MEMS DRIE Filtration

In the clinical/microbiological laboratory there are currently several ways of separating specific cells from a fluid suspension. Conventionally cells can be separated based on size, density, electrical charge, light-scattering properties, and antigenic surface properties. Separating cells using these parameters can require complex technologies and specialist equipment which may damage sensitive cells. The pumping mechanism described here leaves samples undamaged either mechanically or chemically unlike many other current filtration techniques. This paper proposes new Bio-MEMS filtration chips manufactured using micro systems technology (MST) that, when used in conjunction with an optical microscope and a syringe, can filter and grade cells for size without the requirement for additional expensive equipment. These chips also offer great versatility in terms of design and their low cost allows them to be disposable, eliminating sample contamination. This paper describes how the device operates, how it was made and reports on preliminary results determined using a dvice.

ISBN: 0-9767985-0-6
Pages: 844
Hardcopy: $109.95