Nanotech 2003 Vol. 1
Nanotech 2003 Vol. 1
Technical Proceedings of the 2003 Nanotechnology Conference and Trade Show, Volume 1

Computational Biology Chapter 2

Syntenic Reconstruction of Microbial Chromosomal Mutations

Authors: R. Cutler and A. Gambis

Affilation: Bard College, United States

Pages: 21 - 23

Keywords: synteny, microbial, chromosomal mutation

In this paper, we propose a method to reconstruct the evolutionary history of chromosomal modifications between groups of related species using conservation of synteny. Starting from the most closely related species, as defined by the currently established taxonomy for microbial species, a minimal parsimony class of chromosomal events can be built. This class contains three types of regions: regions that are completely conserved, regions with some form of chromosomal modification, for example a gene duplication or deletion, and regions with an inversion. From this data alone, it is not possible to determine which chromosome form is ancestral, but using a closely related lineage these ambiguities can be resolved. In this way an ancestral genome arrangement can be determined for clades of species and then these classes can be aligned to resolve regional ambiguities.

ISBN: 0-9728422-0-9
Pages: 560

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