2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Micro-photonic cylindrical waveguide based protein biosensor

S.K. Padigi, K. Asante, V.S. Reddy Kovvuri, R.K. Reddy, A. La Rosa and S. Prasad
Portland State University, US

photonics, optical biosensor, protein detection

Optimal biosensor design for detection of label-free biomolecules should be simple, sensitive and particularly adept at tasks such as bio-molecule recognition. High sensitivity is of critical importance, since at times samples comprise only a few molecules. A wide range of optical micro-cavities have been investigated for biosensing including spherical, ring and disc-like structures. All the microcavities have been fabricated using complex clean room based photolithography processes. In recent times the use of polymers for fabricating micro-cavities has been developed; for example, hydrogel-basedmicro-cavities have been used for detecting bio-molecules at micromolar detection sensitivity. Most recently, DNA detection with nanomolar detection sensitivity using spherical micro-cavities has been demonstrated). The limitations of the existing optical micro-cavity based biosensing techniques lie in the expensive techniques involved in the precision based fabrication, which results in a low throughput device turnout . We present here a rapid prototyping optical microcylindrical waveguide based biosensing technology, where a photo-resist polymer is used to develop high throughput microscale structures that are surface sensitized to detect proteins of interest.

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