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Microfluidics and Miniaturized Arrayed Assays for the Evaluation of Biological Diversity

Gregor Dernick

Gregor Dernick

Lab Head Microtechnologies
Microtechnologies and Automation, Discovery Enabling Sciences, Pharmaceuticals Division
F. Hoffmann-La Roche AG, Switzerland

Gregor Dernick received his degree in chemistry in 1996 from the University in Heidelberg, Germany. During his PhD at the Max-Planck-Institute for Medical Reserach in Heidelberg and at the School of Applied and Engineering Physics of Cornell University, Ithaca, NY he studied single-cell electrophysiology. He developed a combination of patch clamp and amperometry (“Patch Amperometry”) to allow simultaneous high-resolution recordings of fusion and release of secretory vesicles of sizes down to 100 nm. He received his PhD from the University of Heidelberg in 1999. During his Postdoctorate at the Nanobiotechnology Center at Cornell he was involved in the development of a microfabricated electrochemical array detector to monitor release of individual cells in a spatially-resolved manner.

In 2001 he joined the group of Microtechnologies and Automation for pharma reserach of F. Hoffmann-La Roche Ltd in Basel, Switzerland. Here he establishes different technologies for biomolecular patterning and miniaturized assays, for the application in pharmaceutical reserach. Among them is the spotting of Oligonucleotides, cDNA, and Plasmids, as well as Proteins and Antibodies. He also co-develops the microchannel assay for the rapid multiplexed analysis of sub-microliter volumes of samples for a multitude of proteins.

His further interests are in modification of surfaces for tuning both microfluidic properties and biomolecular adhesion, low volume liquid handling, and miniaturized technologies for biomolecular interaction analysis.

Speaking in the special symposium on Micro & Nano Fluidics.

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