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Symposium on

„Micro- and Nanofluidics: Towards a Design Methodology“

Symposium Sponsor:  LioniX BV
Symposium Chair:  Steffen Hardt, Darmstadt University of Technology, DE

Confirmed Speakers

Chih-Ming HoBio-Nano-Informatics Fusion
Chih-Ming Ho, University of California, Los Angeles
(speaker biography)

Symposium Program


Monday May 9

1:30 Micro and Nano Fluidics Design - 1, Sponsored by LioniXGrand Ballroom E
 Session chair: Steffen Hardt, TU-Darmstadt, DE
1:30 Design Paradigms and Methodologies for Microfluidics
S. Hardt, Darmstadt University of Technology, DE
2:00 Lab-on-a-Chip by Digital Microfluidics
C.-J. Kim, UCLA, US
2:30 Addressing Biocomplexity Through Microfluidics: From Systems Biology to Biological Systems
T. Thorsen, Massachusetts Institute of Technology, US
3:00 Flat Fluidics: Programmable On-Chip Networks for Biological and Chemical Applications
A. Wixforth, University of Augsburg and Advalytix AG, DE
4:00 Micro and Nano Fluidics Design - 2, Sponsored by LioniXGrand Ballroom E
 Session chair: Steffen Hardt, TU-Darmstadt, DE
4:00 Applications of Topology Optimization in the Design of Micro- and Nanofluidic Systems
F. Okkels, L.H. Olesen and H. Bruus, Technical University of Denmark, DK
4:20 Micro Multi-Phase Flows in CFD Simulations
F. Schönfeld, Institut für Mikrotechnik Mainz / IMM, DE
4:40 System Simulations of Complex Electrokinetic Passive Micromixers
Y. Wang, Q. Lin and T. Mukherjee, Carnegie Mellon University, US
5:00 Coherent Nonlinear Chromatography
E.B. Cummings, Sandia National Laboratories, US
5:20 Computational Analysis of On-line Coupled ITP-CE
M. Horner, Fluent, Inc., US

Tuesday May 10

10:30 Nanofluidics and TransportSalon A-B
 Session chair: Steffen Hardt, TU-Darmstadt, DE
10:30 Multiscale Modeling of Nanoflows
G. Drazer, A. Acrivos, B. Khusid and J. Koplik, New Jersey Institute of Technology, US
10:50 Scaling of Electroosmotic Flow and Ionic Conductivity in Nanochannels
R. Qiao and N.R. Aluru, Beckman Institute for Advanced Science and Technology, US
11:10 Characterization of a Solid State DNA Nanopore Sequencer using Multi-Scale (Nano-to-Device) Modeling
J.W. Jenkins, D. Sengupta and S. Sundaram, CFD Research Corporation, US
11:30 Understanding the Cytoplasmic Transport of Synthetic Gene Vectors
C. Pangarkar, A.-T. Dinh and S. Mitragotri, University of California Santa Barbara, US
11:50 Multiscale Computation of Fluid and Ion Transport in Nanochannels: The Effect of Partial Charges
S. Joseph, A.N. Chatterjee and N.R. Aluru, Beckman Institute of Advanced science and technology, US
4:00 Microfluidics: Electrokinetic TransportLa Jolla - Los Angeles
 Session chair: Steffen Hardt, TU-Darmstadt, DE
4:00 Electrokinetic Instabilities and Sample Stacking
H. Lin, M.H. Oddy and J.G. Santiago, Stanford University, US
4:30 High Sensitivity, Microfluidic Immunoassays utilizing DNA-conjugated Antibodies to Accelerate the Electrophoretic Separation of Antigen-Antibody Complexes.
H.G. Wada, T. Kawabata, I. Kazakova, A. Simeonov, C. Park, P. Kechagia, M. Spaid, M. Watanabe and S. Satomura, Wako Pure Chemical Industries Ltd., US
4:50 Microfluidic Injector Models Based on Neural Networks
R. Magargle, J.F. Hoburg and T. Mukherjee, Carnegie Mellon University, US
6:30 Nano Fluidics and TransportGrand Ballroom E-F
- Nanofilament Directional Control within a Hybrid Microelectronic Actin-Myosin Motility Assay via Integrated Electric Field Addressing
P. Famouri, H. Takatsuki, L.A. Hornak, K. Brown, R. Chilakamarri, A. Timperman, J. Lenke, P. Gannett and K. Kohama, West Virginia University, US
- Hyperselective and Targeted Separation of Analytes Using Multiple Dynamic Equilibrium Gradients Approach
Y. Markushin, A. Dawoud and R. Jankowiak, Ames Laboratory USDOE, US
- Modeling of Fluid Flow Through Polymer Grafted Smart Nanofluidic Channels
S.P. Adiga and D.W. Brenner, Argonne National Laboratory, US
6:30 Micro Fluidics and Lab-on-ChipGrand Ballroom E-F
- An Analytical Model for the Prediction of Microdrop Extraction and Splitting in Digital Microfluidics Systems
J. Berthier, O. Raccurt, Ph. Clementz, D. Jary, P. Claustre, C. Peponnet and Y. Fouillet, CEA-LETI, FR
- Thermal Modulation and Instability of Viscous Microjets
E.P. Furlani, Eastman Kodak Company, US
- Development of Microfluidic Device for Heterogeneous Immunoassay on Polystyrene Platform with Electroosmotic Control
M. Pribyl, D. Snita and M. Marek, Institute of Chemical Technology Prague, CZ
- Fast and Sensitive DNA Hybridization Through Micro- Fluidics
A.H. Marafie and M.J. Madou, University of California, Irvine, US
- Investigation of Volume of Fluids (VOF) Method and System Models for Design of Microfluidic Ink Delivery Apparatus for Dip Pen Nanolithography (DPN)
D. Banerjee, Texas A&M University, US
- Modular Design Approaches for MicroFluidic Systems
M.J. Gilde, H. van den Vlekkert, H. Leeuwis and A. Prak, CapiliX BV, NL
- Mechanical Behavior of Micro-Drops in EWOD Systems: drop extraction, division, motion and constraining
J. Berthier, Ph. Clementz, D. Jary, O. Raccurt, P. Claustre, C. Peponnet and Y. Fouillet, CEA-LETI, FR
- The Manufacture and Preliminary Testing of a Novel Bio-MEMS Filtration Chip
P.T. Docker, M. Prince, P.K. Kinnell, M.C.L. Ward and X. Ma, Birmingham University, UK
- A Novel Microrheometer for Measuring Rheological Properties of Microquantities of Fluids
C.S. Lo, P.D. Prewett, M.C.L Ward and P.T. Docker, University of Birmingham, UK
- Design, Modelling and Simulation of a PZN-PT Actuated Micropump
D. Malleo, C. Haas and M. Kraft, University of Southampton, Microelectronics Group, UK

Wednesday May 11

10:30 Cell and Particle HandlingSalon J-K
 Session chair: Srinivas Iyer, Los Alamos National Labs, US
10:30 Highly Selective Capture and Transport of Rare Cells in Microfluidic Channels
M.D. Ward and P. Grodzinski, Los Alamos National Laboratory, US
10:50 Biomimetic Design of a Microfluidic Device for Auto-separation of Leukocytes from Whole Blood
S.S. Shevkoplyas, T. Yoshida, L.L. Munn and M.W. Bitensky, Boston University, US
11:10 A Microfluidic System for Continuous Magnetophoretic Separation of Suspended Cells Using Their Native Magnetic Properties
K-H Han and A. Bruno Frazier, Georgia Institute of Technology, US
11:30 Strong DC and Low-Frequency AC Fields for the Manipulation of Particles and Fluids in Microfluidics
A. Kumar, Z. Qiu, B. Khusid, M. Yeksel and A. Acrivos, New Jersey Institute of Technology, US
11:50 Numerical Modelling of a Microfluidic Ultrasonic Particle Separator
R.J. Townsend, M. Hill, N.R. Harris, N.M. White and S.P. Beeby, University of Southampton, UK
1:30 DNA MicrofluidicsSalon J-K
 Session chair: Steffen Hardt, TU-Darmstadt, DE
1:30 Rapid DNA Amplification in Buoyancy Driven Closed Loop Microfluidic Systems
N. Agrawal and V.M. Ugaz, Texas A&M University, US
1:50 Fast DNA Immobilization and Hybridization on a CD (Compact Disc) Microfluidic Platform
G. Jia, K.S. Ma, H. Kido, J.V. Zoval and M.J. Madou, University of California at Irvine, US
2:10 Accurate High-throughput Gene Synthesis Using Programmable DNA Microfluidic Microchips
J. Tian, H. Gong, N. Sheng, X. Zhou, E. Gulari, X. Gao and G.M. Church, Harvard Medical School/Genetics, US
2:30 Enhanced Separation Performance in Microfabricated Electrophoresis Devices by Electric Field Induced Collection and Metering of DNA
F.A. Shaikh and V.M. Ugaz, Texas A&M University, US
3:30 Microfluidics ApplicationsSalon J-K
 Session chair: Steffen Hardt, TU-Darmstadt, DE
3:30 Inkjet Assisted Micro-Scale Cooling of Electronics
R.K. Sharma, C.E. Bash and C.D. Patel, Hewlett Packard Co. Laboratories, US
3:50 A Computational Model for the Design of ElectroWetting On Dielectric (EWOD) Systems
A.S. Bedekar, J.W. Jenkins and S. Sundaram, CFD Research Corporation, US
4:10 Dimensioning of a New Micro-Needle for the Dispense of Drugs in Tumors and Cell Clusters
J. Berthier, F. Rivera, P. Caillat and F. Berger, CEA-LETI, FR
4:30 Electrostatic Droplet Ejector with Monolithic Fabrication of Nozzle
S.H. Lee, D.Y. Byun, H.S. Ko, Y. Kim, J.H. Yang, S.J. Han, S.U. Son and J.T. Oh, Konkuk University, KR
4:50 The Application of Micro Reactors for Chemical Synthesis: How small is required?
P. Watts, University of Hull, UK


Micro- and nanofluidic technologies have experienced a rapid development over the past few years. They find applications in such areas as Micro Total Analysis Systems, microelectronics cooling, e-paper, or microreaction devices, some of which are expected to make a considerable economic impact in the near future. Furthermore, nanotechnology often requires handling of molecules in liquid phase, so microfluidics can be regarded as an enabling technology providing a platform for manipulations occurring at even smaller length scales.

Compared to microelectronics, the design process for micro- and nanofluidic systems is in its infancy, and standard technological building blocks and unit operations are largely missing. The development of a corresponding design methodology requires the development of modeling and simulation tools as well as experimental procedures for validation and testing. The aim of this symposium is to give an overview of current trends in micro- and nanofluidics, with special emphasis on approaches taking steps towards a design methodology.

Topics of interest are modeling and simulation approaches, especially those which are based on a reduced number of degrees of freedom and allow a rapid assessment of system designs. Another emphasis will be on system development, i.e. the integration of a number of micro- and nanofluidic components into complete systems. The symposium also includes methods for evaluation and testing of corresponding systems, where reliability analysis plays a considerable role. Finally, any developments towards technological building blocks for performing standard microfluidic operations will be appreciated.

From the presentations given in this symposium it should be possible to recognize the current trends in micro- and nanofluidics and some promising strategies to overcome the main obstacles towards further commercialization of this promising new technology.

For further information, please contact


  • Fluid Transport
  • Hydrophobic / Hydrophilic Filling and Dispensing
  • Pressure Driven Flow, Taylor-Aris Dispersion & Sample Mixing
  • Particle/Cell Transport
  • Molecular Transport
  • Mass Transport or Kinetics-Limited Binding
  • Antigen-Antibody, Ligand-Receptor Binding
  • Multi-Protein, Multi-Receptor, Competitive Binding
  • DNA Hybridization
  • Surface or Volume-Immobilized Enzyme Catalysis
  • Electroosmosis/Electrophoresis
  • Electrochemical Sensing
  • Conventional & Traveling Wave Dielectrophoresis
  • Electromagnetics, AC/DC Electric Fields & Joule Heating
  • Electrokinetic Injection

Impacted Industries

  • Pharma
  • Biotech
  • Health Care Providers
  • Semiconductor
  • Chemicals Processing
  • Market Analysts, Investors, Legal Experts, Regulatory Authorities
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