Study on the Composite with Sequential and Sustained Release of Multiple Growth Factors for Bone Repair

Liao Y., Liu T.Y.
Institute of Biomedical Engineering, National Yang-Ming University, TW

Keywords: bone repair, bone tissue engineering, growth factor, injectable hydrogel, microsphere, sequential release, sustained release

In this study, a PLGA/PVA microsphere and a chitosan-based hydrogel loading FITC were prepared to be a composite. The encapsulation of FITC in PLGA/PVA microspheres and the bonding of crosslink in chitosan-based hydrogel were confirmed. The composite succeeded in sequential and sustained release and achieved a high cell viability. Most importantly, the composite could be applied through an injectable style, which accommodates to clinical use. This composite can then be applied to encapsulate and release multiple growth factors for bone repair and bone tissue engineering.

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Journal: TechConnect Briefs
Volume: 2, Nanotechnology 2014: MEMS, Fluidics, Bio Systems, Medical, Computational & Photonics
Published: June 15, 2014
Pages: 359 - 362
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech
Topics: Biomaterials, Materials for Drug & Gene Delivery
ISBN: 978-1-4822-5827-1