Castro N.J., O’Brien C., Zhang L.G.
The George Washington University, US
Keywords: growth factors, Interface, nanospheres, osteochondral, scaffold
The current work focused on the development and evaluation of a novel biomimetic biphasic nanocomposite scaffold for osteochondral interfacial tissue engineering. Tissue-specific growth factor-encapsulated nanospheres were manufactured via a wet electrospray technique and incorporated within the respective layer of our biphasic model. Human bone marrow derived mesenchymal stem cells were seeded, cultured, and evaluated. Two-week differentiation results illustrated increased collagen and calcium deposition on nanosphere containing scaffolds when compared to other test samples.
Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy (Volume 3)
Published: May 12, 2013
Pages: 183 - 186
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech
Topic: Biomaterials
ISBN: 978-1-4822-0586-2