Authors: I.H. Karampelas, E.P. Furlani, A. Nunez, G. Vizzeri
Affilation: State University of New York at Buffalo, United States
Pages: 354 - 357
Keywords: eye biomechanics, intraocular pressure, IOP, intracranial pressure, ICP, optic nerve sheath dilatation, ONSD, intracranial fluid structure interactions, optic nerve stress, stress and strain of eye tissue
The human eye is a complex organ consisting of multiple different tissues with varying mechanical properties and functionality. Hence, there are many aspects of the biomechanical behavior of the eye that are not understood. In this presentation, we introduce multiscale computational models that can be used to predict the biomechanical behavior of the eye taking into account effects such as elevated intracranial and intraocular pressure, ICP and IOP. Pressure related effects have drawn international attention recently due to reported observations of ocular abnormalities in astronauts. A multiscale modeling approach is essential for analyzing physiological effects of the eye as these occur in anatomical features that span multiple length scales. Our modeling effort involves the use of computational fluid dynamics with fluid structure interactions (CFD-FSI) for predicting flow, pressure and tissue deformation. We use numerical finite element-based structural analysis to predict the deformation of ocular tissues under variations in ICP/IOP loading. We also use lumped-element analysis for predicting cephalad fluid shifts that give rise to changes in pressure on the tissues of the posterior eye. We demonstrate the models via application to idealized eye geometries and discuss model validation using a human cadaveric eye model and head-down bed rest studies.