Authors: J. Wang, Y. Long, C. Tao, H. Liu, H. Zhu, X. Zhou
Affilation: National University of Defense Technology, China
Pages: 239 - 242
Keywords: graphene oxide, drug carrier, ph-sensitive, controlled release
Graphene oxide (GO) offers large surface and novel biocompatible properties that are currently being explored for advanced drug carriers. GO has a one-atom-thick two dimensional carbon system, which contains several kinds of oxygen functional groups on its basal planes and edges. Benefit from its great surface area, well-dispersion, novel biocompatible and lots of π-π stacking and H-bonding site, GO become a promising nano material as a drug carrier substance. Here we report nano GO as drug carriers and investigate its drug loading and release properties for Benazepril, Captopril and Losartan , which are used for antihypertensive treatment with short action time and poor water solubility. The loading capacity depends on the initial ratio of drug/GO ratio. The max loading of these three drugs are 1.12 mg/mg (Benazepril), 0.49 mg/mg (Captopril) and 0.30 mg/mg (Losartan) respectively.The release behaviors of these three drugs are pH-depended. The total amount of drug released in acidic environment is high than any other pH value. The pH-depended release property is due to the partial dissociation of hydrogen-bonding interaction under different pH conditions. The pH-dependent release property makes it possible to release drugs at determined target organs with different pH such as stomach and intestines.