Authors: R. Prasanth, D. Gopinath
Affilation: Pondicherry Central University, India
Pages: 206 - 209
Keywords: scanning electro chemical microscopy, ZnO nanoparticles, cancer cells, respiration study
In recent years, there is an overwhelming interest in using nanoparticle for cancer therapy. Many reports show selective cytotoxicity of nanoparticles over cancer cells. However, the mechanism of such behavior is yet to be discovered. Hence, in addition to the conventional assays we need to develop novel techniques useful to explore the physical as well as chemical variations due to nanoparticle-live cell interaction. Scanning Electrochemical Microscopy provides an opportunity to measure the real time chemical process at cell proximity in the presence of nanoparticle. Herein, the respiration process in nasopharyngeal cancer cells has been investigated with the help of Scanning Electrochemical Microscopy. The cell viability has been tested with MTT assay. The results show that ZnO nanoparticles have time and dose dependent effect in nasopharyngeal cancer cells and the cell respiration rate decreases with time.