Authors: V. Leung, R. Hartwell, E. Faure, H. Yang, A. Ghahary, F. Ko
Affilation: University of British Columbia, Canada
Pages: 166 - 169
Keywords: electrospinning, drug delivery, PCL, PVA, PLGA, drug release control, nanofibres
This study aims to design methods for controlling drug release from polymer nanofibres, and use these methods as a guide for designing nanofibre wound dressings with customizable release profile for a range of drugs. The outcome of this research will greatly benefit the massive number of patients of both acute and chronic wounds. The great demand from these patients translates to massive cost to the society, stemming from treatment, long-term healthcare and loss of productivity, thereby necessitating improved technology to more appropriately address current challenges. Although electrospun polymer nanofibres have been shown as a potential scaffold material for tissue regeneration, the nanofibrous morphology alone is not sufficient to address current challenges, as effective dressings must also be able to stimulate and regulate various activities in the healing process. With this in mind, the ability to control drug release enables a mechanism for regulating the intricate native processes involved with wound healing.