Authors: B.A. Katsnelson, L.I. Privalova, T.D. Degtyareva, S.V. Kuzmin, M.P. Sutunkova, I.A. Minigalieva, E.P. Kireyeva, M.Y. Khodos, V.Y. Shur, E.V. Nikolaeva, I.E. Valamina, L.G. Tulakina, S.V. Pichugova, J.B. Beykin
Affilation: Federal State Institution of Sciences Medical Research, Russian Federation
Pages: 537 - 540
Keywords: nanoparticles, magnetite, toxicity
Assessment of toxicity of 10 nm, 50 nm and 1 um Fe3O4 particles based on shift in the cell population of the broncho-alveolar lavage fluid after their intratracheal instillation into lungs of rats and on a set of indices of the organism’s status following repeated intaperitoneal injections showed that, in equal mass doses, nanoparticles were far more toxic than microparticles but induced a more active protective response of alveolar phagocytosis. The latter fact was established with optical, electronic, and SE atomic force microscopy.