Bio Nano Materials – TechConnect Briefs

Responsive Materials

Lo Presti C., Merck Serono, IT

Continuous advances in polymer chemistry are enabling the synthesis of novel responsive biomaterials. This class of biomaterials are polymers able to undergo significant changes in their properties in response to external stimuli. Depending on their [...]

A Helical Peptide can Mediate Electron over 120 Å by Hopping Mechanism

Arikuma Y., Nakayama H., Morita T., Kimura S., Kyoto University, JP

We have studied long-range electron transfer through various lengths of helical peptides from 8 mer (24 Å) up to 80 mer (120 Å) in self-assembled monolayers prepared on a gold surface. Helical peptides carrying a [...]

Colloido-Polymersomes: Capsules consisting of a composite layer of particles and polymer

Shum H.C., University of Hong Kong, HK

We present an approach to fabricate capsules consisting of a composite layer of particles and block copolymers . The capsules are fabricated by the directed assembly of block copolymers at the interfaces of a double [...]

Attenuated-Affinity Biotin Analogs for Catch-and-Release with Streptavidin

Corry S., Ying L-Q, Branchaud B., Life Technologies, US

The binding between streptavin and biotin, which is one of the strongest non-covalent interactions known in nature, is used ubiquitously in molecular biology. However, when a biotinylated molecule is captured for testing purposes and cannot [...]

Biomimetic Polyurethanes for Regenerative Medicine

Ciardelli G., Sartori S., Serafini P., Boffito M., Caporale A., Silvestri A., Bernardi E., Boccafoschi F., Politecnico di Torino, IT

Degradable linear polyurethanes from non toxic building blocks were prepared. Bioactive peptides were incorporated in polyurethane chains, in order to create a synthetic equivalent of the Extracellular Matrix, able to mimic natural tissue. Both cell [...]

Biomimetic High Filler Content Composites using Bisphenol-A Ethoxy Diacrylate

Daud N., Shanks R.A., RMIT University, AU

Materials were prepared similar to nacre with its layered structure of high filler content. Nacre is based upon about 95 %·w/w calcium carbonate as a composite with a layered block structure. Nacre has high modulus, [...]

Nanoviricides as Anti-Influenza Agents

Diwan A.R., Tatake J.G., Barton R.W., Menon K., Nanoviricides, Inc., US

Nanoviricides® anti-influenza agents are designed to mimic a natural host cell receptor to which all influenza A viruses bind and infect host cells. A nanoviricide is composed of a flexible polymer backbone with virus-specific ligands [...]

Nanomaterials can influence living biological systems with nanometer sensitivity

Sabella S., Brunetti V., Maiorano G., Rizzello L., Sorce B., Vecchio G., Galeone A., Cingolani R., Pompa P.P., Italian Institute of Technology, IT

We show the different response of human neuroblastoma cells line to gold surfaces with different levels of nanoroughness, finding out that neurons are capable to sense and actively respond to these nanotopography features, with a [...]

Mechanistic studies of in vitro cytotoxicity of PAMAM dendrimers in mammalian cells

Mukherjee S.P., Lyng F.M., Garcia A., Davoren M., Byrne H.J., Focas Research Institute, Dublin Institute of Technology, IE

The in vitro cytotoxic response of human dermal and colon cell lines to structurally well-defined full generation cationic dendritic polyamidoamine (PAMAM) nanoparticles of generations G4, G5, G6 was investigated. PAMAM dendrimers have been demonstrated to [...]

Enhanced proliferation of osteoblast cells on mechanically deformed elastic membranes

Toworfe G.K., Composto R., Ducheyne P., Regent University College of Science and Technology, GH

Proliferation of osteoblast cells is enhanced on functionalized elastically deformed membrane

Cellulose Fiber and Nano-Fiber Composites based on Castor Oil-Polyurethane Matrix

Ansari M.N.M., Shanks R.A., Universiti Tenaga Nasional, MY

The bimodal combination of cellulose fibre dimensions resulted in complementary properties from the same chemical composition. The nano-cellulose fibers provided thixotropy to the castor oil based reactants. The composites exhibited strength, toughness and a modulus [...]

Nanoparticles co-encapsulating hVEGF and hAng-1 can induce mitotic and antiapoptotic effect on vascular endothelial cells

Khan A.A., Paul A., Abbasi S., Prakash S., McGill University, CA

This study demonstrates the combined effect of the angiogenic proteins, hVEGF and hAng-1, coencapsulated in human serum albumin (HSA) nanoparticles (NPs), towards human umbilical vein endothelial cells (HUVECs) and an evaluation of the potential application [...]

RAFT Polymerisation for delivery of bioactives

Chiefari J., CSIRO, AU

The RAFT (Reverse Addition-Fragmentation chain Transfer) process is a ground breaking technology that offers unprecedented control over the composition, functionality and architecture of polymers. The versatility of the RAFT technology provides enormous potential for designing [...]

Fabrication of magnetic bio-Au nanoclusters by using SlaA-layer ghosts of Sulfolobus acidocaldarius as a template

Selenska-Pobell S., Reitz T., Geissler A., Herrmannsdörfer T., Merroun M., Forschungszentrum Dresden Rossendorf, DE

We demonstrate that the outermost proteinaceous surface layer SlaA of the thermo acidophilic archaeon Sulfolobus acidocaldarius is an excellent matrix for preparation of bio-Au nanoclusters. The archaeal bio-Au nanoparticles are significantly bigger and possess considerably [...]

Nanoskin for Medical Applications

Basmaji P., Innovatecs, BR

The present paper describes NANOSKIN production for medical applications. Nanoskin is produced from the bionanotechnology process. Nanoskin is a highly hydrated pellicle made up of a random assembly of ribbon shaped fibers less than 100 [...]

Highly stable and orientationally coupled gold nanoparticle antibody conjugates for sensitivity improvement in LFIA

Ijeh M., Vossmeyer T., Weller H., University of Hamburg, DE

LFIAs are used in the investigation of a variety of bio-molecular binding interactions and they remain the primary means for point of care and fast detection of analytes including pathogens and toxins. In a novel [...]

Phase Behavior and Macroscopic Processing of Single-Walled Carbon Nanotube – Lysozyme Dispersions

Horn D.W., Davis V.A., Auburn University, US

Lysozyme (LSZ) facilitates the dispersion of single-walled carbon nanotubes (SWNT) while maintaining its’ antibacterial activity through macroscopic processing. The structural and enzymatic nature of LSZ makes possible the dispersion of SWNT for processing into macroscopic [...]

Small Photostable Photoswitchable Quantum Dots as Nanotools for Live Cell Imaging

Díaz S.A., Jovin T.M., Jares-Erijman E.A., University of Buenos Aires, CIHIDECAR, CONICET, AR

We have developed a novel surface architecture for the generation of biocompatible and stable photoswitchable quantum dots (psQDs). The system is based on Förster Resonance Energy Transfer (FRET) from a QD donor to diheteroarylethenes photochromic [...]

Hybrid silica-coated palsmonic-magnetic biomarkers

Sotiriou G.A., Hirt A.M., Lozach P-Y., Teleki A., Krumeich F., Pratsinis S.E., Particle Technology Laboratory, ETH Zürich, CH

In this study, hybrid silica-coated plasmonic-magnetic nanoparticles have been synthesized in one-step by a scalable flame aerosol technology. The effect of the silica in the stability of the nanoparticles, as well as their biocompatibility are [...]

Synthesis and characterization of new nanoparticles formed by milk whey proteins submitted to a thermal gelation process

Lopes J.R., Coimbra J.S.R., Teixeira A.V.N.C., De Oliveira E.B., Federal University of Viçosa, BR

In this work, nanostructures formed by the two whey proteins (alpha-lactoalbumin and beta-lactoglobulin) were synthesized througha thermal gelation process. The obtained proteic nanoparticles were characterized by using dynamic light scattering, transmission electron microscopy and atomic [...]

Characterization of rMOMP-187 Peptide Encapsulated in PLGA 50:50 Nanoparticles

Taha M., Singh S.R., Butler C., Nyairo E., Dennis V.A., Alabama State University, US

The design of an immunization regimen capable of inducing sustained genital mucosal Th1 response is the current goal for a vaccine for humans to control the severe complications of genital infection by C. trachomatis. In [...]

Synergistic effects in mixed micellization between natural and synthetic block copolymers

Portnaya I., Khalfin R., Kesselman E., Danino D., Technion – Israel Institute of Technology, IL

Amphiphilic block copolymers and mixtures of amphiphiles find broad applications in numerous nano-technologies. In our previous study, we showed that interactions between a biological charged diblock copolymer, beta-casein, and a synthetic uncharged triblock copolymer, Lutrol [...]

siRNA and Paclitaxel Loaded PEG-PCL-PEI Tri-block Polymeric Micelle for Gene and Chemo-therapy Applications in Multidrug-resistance cancer cell

Hsu C.Y., National Chung Hsing University, TW

An annoying problem of chemotherapy was the drug resistance of cancer cell which was expression of multidrug-resistance associated proteins and resulted in ineffective treatment. To conquer this problem, a small interfering RNA (siRNA) molecule and [...]

Bioactivation of Titanium Surfaces by Femtosecond laser Processing

Tavangar A., Tan B., Venkatakrishnan K., Ryerson University, CA

In this study, we propose a novel yet simple method to generate titanium oxide 3-D nanofibrous structures on the titanium implants using femtosecond laser machining. The femtosecond laser pulses hit the titanium substrate and generate [...]

Biological effects of PLA-TCP nanocomposites on osteoblastic cells

Kim H.W., Kim J.W., Kim T.I., Lee H.-H., Lee S.-P., Kim H.W., Kim J.W., Kim T.I., Kim H.W., Kim J.W., Kim T.I., Lee H.-H., Lee S.-P., Seoul National University, KR

Composite substrates are considered as prospective matrix to populate and support cells in the bioengineering field. Synthetic degradable biomaterials, including poly(lactic acid) (PLA) and tricalcium phosphate (TCP), are widely used for matrix scaffold. In present [...]

Photo-destruction of cancer cells by NIR irradiation and graphene nano-sheets

Abdolahad M., Mohajerzadeh S., Janmaleki M., Akhavan O., University of Tehran, IR

In this paper, we present a novel cancer therapy method based on graphene inclusion in the cell solution and irradiation of the solution by near infrared lasers. The effect of various parameters such as graphene [...]

Poly(Lactic Acid) Hemp Composites Combined with Nano-Silica

Mustapa I.R., Ansari M.N.M., Shanks R.A., Universiti Tenaga Nasional, MY

An important issue for all composites is reduction of creep. The reinforcing fibers dramatically reduce creep, however nano-composites can improve tensile properties and toughness. The aim of this work is to prepare and characterize PLA [...]

Starch/MWCNT/Epoxy Composites for Biodegradable Batteries

Ansari M.N.M., Shanks R.A., Kong I., Universiti Tenaga Nasional, MY

Currently, the vast majority of plastics are made from petroleum-based synthetic polymers that do not degrade in a natural environment and their disposal poses a serious problem. An environmentally-conscious alternative is to design polymer nanocomposites [...]

Preparation, Characterization and Antioxidative Activity of Anti-aging Nanoemulsion and Lipid Nanoparticls

Xia Q., Wang H., Wang J., Tang J., Wang H., Wang J., Southeast University, CN

Nanoemulsions (NEs) and lipid nanoparticles (LNs) were regarded as suitable nanosized carriers of water-insoluble active components. These nanosized carriers could be used to load with drugs, nutrients and cosmetic actives and provide the appropriate application [...]

Titanium Tungsten Coatings for Bioelectrochemical Applications

Wierzbicki R., Amato L., Lopacinska J., Heiskanen A., Emneus J., Boggild P., Molhave K., DTU Nanotech, DK

Our research interest is the combination of carbon nanotube electrochemistry with nanostructured substrates capable of cell scaffolding. Therefore, an adhesion / electric connection coating with good biocompatibility, PECVD compatibility and electrochemical stability needs to be [...]

Three-dimensional cell instructive scaffolds to direct stem cell fate

Viswanathan P., Chirasatitsin S., Reilly G., Engler A., Battaglia G., University of Sheffield, UK

Novel biomaterials design rarely incorporates the range of topographical (10nm – 100um) and chemical cues required to influence cell behaviour. Of particular interest is controlling human mesenchymal and embryonic stem cell fate. Recently it has [...]

Antioxidant activity of fullerene C60 against OH free radicals: A Quantum Chemistry and Computational Kinetics Study

Iuga C., Universidad Autónoma Metropolitana, MX

Fullerenes are considered to be the world’s most efficient radical scavenger, and represents an attractive tool for biological applications. Indeed, it have been demonstrated in vivo and in vitro, that fullerenes and related structures reduce [...]

Synthesis and Characterization of Anti-CD4 monoclonal antibody-conjugated Magnetic Poly (glycidyl methacrylate) Particles and their Application on CD4+ Lymphocyte Separation

Pimpha N., Chaleawlert-umpon S., Chruewkamlow N., Kasinrerk W., National Nanotechnology Center, TH

To develop an efficient magnetic system for separation of CD4+ lymphocytes, we design a simple, specific, and cost-effective CD4 separation system without the need for column separation technique. Novel immunomagnetic particles have been prepared for [...]

Nanoskin Bacterial cellulose structured- Towards the development of regenerative medicine

Olyveira G.M., Costa L.M.M., Basmaji P., UFABC, BR

Bacterial cellulose (BC) has established to be a remarkably versatile biomaterial and can be used in wide variety of applied scientific endeavors, especially for medical devices. In fact, biomedical devices recently have gained a significant [...]

Nanostructured TiO2 and TiO2-Ag antimicrobial thin films

Prasad R.G.S.V., Basavaraju D., Rao K.N., Naveen C.S., Endrino J., Phani A.R., Sri Vishnu College of Pharmacy, IN

Bacterial infection is one of the common clinical problems which can be prevented by coating the surgical instruments or implants with antibacterial properties. The high incidence of infections caused by either fungal or bacteria on [...]

Characterization of Nanostructural Modifications Introduced into a Model Pectic Homogalacturonan by Esterases or Chemical Saponification and Modeling of Enzyme Mode of Action

Cameron R.G., Luzio G.A., Kim Y., Vasu P., Savary B.J., Williams M.A.K., United States Department of Agriculture, Agricultural Research Service, US

Pectin functionality is largely dependent on the ratio of methylesterified/demethylesterified galacturonic acid (GalA) residues present in its polymeric homogalacturonan region (40 – 60 nm in length, 100 – 150 GalA residues) and how the two [...]

Hybrid bionanomaterials based on nanocrystalline TiO2 and catechol-grafted polymers: the effect of composition and morphology on photo and bioactivity

Cellesi F., University of Manchester, UK

We proposed a synthetic strategy for producing hybrid bionanomaterials based on nanocrystalline TiO2 and catechol-grafted polymers. A sol-gel process in organic solvent was developed to grow TiO2 nanocrystals of highly controlled size and surface chemistry, [...]

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