Micro & Nano Fluidics – TechConnect Briefs

Slip boundary conditions in nanofluidics from the molecular theory of solvation

Kobryn A.E., Kovalenko A., National Institute for Nanotechnology, CA

We propose the first-ever derivation and calculation of the hydrodynamic slip length from the first principles of statistical mechanics, based on a combination of linear response theory and equilibrium molecular theory of solvation. The slip [...]

Experimental Study of Drying/Evaporation in an Effective 2D Porous Medium

Yiotis A.G., Tsimpanogiannis I.N., Stubos A.K., National Center for Scientific Research “Demokritos”, GR

Liquid-to-gas phase change, where the mass transfer that drives the process occurs in the gas phase, and the subsequent growth of the produced gas phase within a porous medium, is involved in a wide variety [...]

Continuous Separation of Non-Magnetic Particles through Negative Magnetophoresis inside Ferrofluids

Zhu T., Marrero F., Mao L., The University of Georgia, US

We present a simple, effective and label-free continuous flow non-magnetic microparticle separation scheme in a microfluidic device under static magnetic fields. The separation process is based on negative magnetophoresis and uses water-based ferrofluids. We exploit [...]

Vapor-assisted bonding of poly(dimethylsiloxane) and silicon-based substrates

Sofla A.Y.N., Martin C., University of Toronto, CA

We present a novel method to reliably bond PDMS to glass, Si, SiO2 and PDMS. In this vapor-assisted method the surface of the PDMS is first brought into contact with the substrate. The PDMS-substrate structure [...]

Transitions Between Epithelial and Mesenchymal States in Microfluidic Platform: Acquisition of Malignant and Stem Cell Traits

Aref A.R., Huang R.Y.J., Kang W., Jing S.W., Thiery J.-P., Kamm R.D., SMART, SG

Epithelial–mesenchymal transition (EMT) is an indispensable mechanism during morphogenesis, as without mesenchymal cells, tissues and organs will never be formed. Transitions between epithelial and mesenchymal states have crucial roles in embryonic development and without EMT, [...]

Design of a normally closed piezoelectric micro valve

Zähringer S., Menacher M., Kirchner P., Schwesinger N., Technische Universitaet Muenchen, DE

In a previously published paper a piezoelectric actuator using surface electrodes was investigated in a macro-microscopic approach. Bases on those results a normally closed piezoelectric micro valve was devoloped. Therefore the electrode structures were minimized [...]

Biomolecular Adsorption Phenomena in Electrowetting-Based Digital Microfluidic Devices

Ahmadi A., Devlin K.D., Najjaran H., Holzman J.F., Hoorfar M., University of British Columbia, CA

Digital microfluidic lab-on-a-chip technology has been a new trend in miniaturizing biomedical platforms. However, nonspecific adsorption of these biomolecules has proven to be one the greatest sources of uncertainties for these biofluidic chips. Unwanted adsorption [...]

Novel Parameters for Rapid Blood Separation on a Centrifugal Platform

Gorkin R., Kim T-H., Madou M., Cho Y-K, University of California Irvine, US

Centrifugal microfluidic platforms are emerging as strong candidates for advanced integrated clinical diagnostics for such applications as automated immunoassay processing and nucleic acid analysis, however several implementation challenges limit their widespread use today. Purification of [...]

Multiplexed Localization in Bi-Layer Digital Microfluidic Systems

Abolhasani M., Devlin K.D., Najjaran H., Hoorfar M., Holzman J.F., The University of British Columbia Okanagan, CA

This paper reports a novel system-level design for digital microfluidic (DMF) devices. A DMF multiplexer structure based on a cross-referencing architecture is presented. The design makes use of bi-polar voltage activation and threshold effects to [...]

The Investigation of Electrostatic Induced Inkjet Printing System for the Ejection of a Stable Micro/Nano Droplet

Choi J., Kim Y.J., Son S.U., Chul An K., Lee S., Sungkyunkwan University, KR

Inkjet printing technology has recently attracted considerable attention for a simple fabrication and advanced pattering process during the past decade. In order to manufacture advanced inkjet printing technology, my team has alternatively proposed and investigated [...]

Nanofluidic Channel Based Single Molecular Sensors in Polymer Substrate Fabricated by Novel Nanoimprinting Processes

Wu J., Chantiwas R., Soper S.C., Park S., Louisiana State University, US

One critical challenge in developing innovative nanochannel-based sensors for bio/chemical analyses is to build multiscale structures composed of narrow, long and continuous fluidic nanochannels and microfluidic networks at low cost. We presents a novel process [...]

Toward reliable synthesis of radiotracers for positron emission tomography in PDMS microfluidic chips: Study and optimization of the [18F] fluoride drying process

Tseng W-Y, University of California, Los Angeles, US

Positron Emission Tomography (PET) is a powerful imaging tool with high sensitivity and molecular specificity. Microfluidic systems have shown great promise for the preparation of PET tracers labeled with fluorine-18 (F-18), especially those based on [...]

Droplet actuation in PPy redox process

Tsai Y-T, Choi C-H, Yang E.H., Stevens Institute of Technology, US

A wettability switchable surface will be demonstrated to study the contact angle hysteresis of liquid droplet. Manipulation of surface wettability can be applied in the field of biomedical (cell-surface interaction) and fluids dynamics (friction reduction). [...]

Optimized Surface Patterning Tools for Sub-attoliter Volume Fluid Deposition

Adams M.L., University of South Alabama, US

Micromachined cantilever-based surface patterning tools were optimized to allow submicron diameter printing of fluids on various surfaces. A detailed fluidics model was used to analyze critical variables and determine the best method for optimization. Tools [...]

Novel ultra-fine hollow needles formed on Silicon membranes

Sanaee Z., Mohajerzadeh S., University of Tehran, IR

In this paper we report the realization of record-small hollow needles. The fabrication process does not need a three-dimensional lithography and uses a high precision deep vertical etching in a hydrogenation assisted ion etching unit. [...]

Innovative Strobe-Based Drop Analysis Equipment for Non-Contact Dispensing Systems

Kipman Y., ImageXpert Inc., US

A fully integrated machine-vision based system has been developed for visualization and measurement of drops-in-flight from non-contact dispensing tips. Unlike previously offered systems in the marketplace, this system can be used with any frequency-based jetting [...]

Analysis of prediction capability for internal micro-channels fabrication in polycarbonate and PMMA

Karazi S.M., Brabazon D., Dublin City University, IE

This paper presents a 3^3 factorial Design of Experiment (DoE) and Artificial Neural Networks (ANN) for the prediction of two characteristics of the pulsed Nd:YVO4 laser machined internal micro-channels in Polycarbonate and PMMA glass. Power, [...]

Effect of laser processing parameters and glass type on topology of micro-channels

Ben Azouz A., Brabazon D., Vázquez M., Macka M., Dublin City University, IE

Traditional techniques to manufacture micro-fluidic devices are well established but most are limited to surface micro-fabrication. Laser micro-machining provides an alternative technique for micro-fabrication of devices. This paper presents the fabrication of 3-D micro-channel structures [...]

Study of the phenomenon of meniscus deformation and ejection by pulse voltage and frequency in drop-on-demand EHD printing

Son S., An K., Kim Y.J., Choi J., Lee S., Sungkyunkwan University, KR

EHD (electrohydrodynamics) printing has recently attracted attention for micro/nano size pattern devices due to it can make very small droplet than nozzle diameter and possibility of the use of various ink such as including metal, [...]

Visual Motion Analysis of Nanoplatforms Flow under an External Magnetic Field

Nakhmani A., Etgar L., Tannenbaum A., Tannenbaum R., Lifshitz E., Tannenbaum A., Tannenbaum R., Technion – Israel Institute of Technology, IL

We use the tools of nanotechnology and develop a visual tracking algorithm for motion analysis of nanoplatforms under the influence of an external magnetic field. We have studied quantitative relationships between nanoplatform sizes, fluid flow [...]

Applied Systems and Synthetic Biology in Micro-Fluidic Biochips

Zeng B.J., Benjoe Institute of Systems Bioengineering, CN

The design of bio-molecular systems within cells, it is a recently achievement of synthetic biology and systems biotechnology [1]. Due to the structurity laws [2] of the synthetic biosystems theory: 1).structure integration, coordinative organization of [...]

A Finite Element Analysis for a Supercritical Particulate Process

Bakhbakhi Y., King Saud University, SA

Nonconventional processing methods can lead to the development of materials with unique chemical, physical or mechanical characteristics that make them suitable for specialized applications. One such method is crystallization with supercritical fluids (SCFs), where the [...]

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