Nanotech 2008 Vol. 2
Nanotech 2008 Vol. 2
Nanotechnology 2008: Life Sciences, Medicine & Bio Materials - Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, Volume 2

Nano Medicine & Neurology Chapter 6

Multifunctional Polymeric Nanosystems for EGFR Gene Silencing

Authors: S. Pai, M. Amiji

Affilation: Northeastern University, United States

Pages: 512 - 515

Keywords: muiltifunctional polymeric nanoparticles, siRNA

Abstract:
Multifunctional polymeric nanoparticles with an average size of 200nm could be prepared using the solvent displacement technique. Cetyltriethylammonium bromide (CTAB) surface-modified poly(ethylene oxide)-modified poly(epsilon-caprolactone) (PEO-PCL) nanoparticles encapsulated PTX and siRNA with a loading efficiency > 95%. The multifunctional polymeric nanoparticles could successfully deliver siRNA and chemotherapeutic drug simultaneously to cancer cells to silence EGFR and enhance cell kill respectively


ISBN: 978-1-4200-8504-4
Pages: 808
Hardcopy: $159.95

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