Authors: D. Sri Hartati, W. Tsang, N.M. Briglio, J.E. MacCormac and K. Yokoyama
Affilation: The State University of New York at Geneseo, United States
Pages: 169 - 172
Keywords: amyloid beta, gold colloids
Fibrillogenesis of amyloid beta (AB) monomers is a hallmark of Alzheimer’s disease. The initial stage of this process involves intermediates of Abeta aggregates; which have been the focus of many previous fibrillogenesis studies. We discovered that gold colloidal nanoparticles with an average diameter of 20 nm, coated with AB1-40, exhibited a reversible aggregation process between pH 4 and pH 10, while the rest of the tested gold colloidal particles with the size of 5, 10, 15, 30, 40, 50, and 100 nm did not. This discovery contains a significant implication for the intial step of fibrillogenesis where intermediates of fibrillogenesis exist, while the form of the intermediate is still controversial. Our information on a possible intermediate involves a metal surface which is intended to utilize the nano-scale interfacial environment geometrically mimicking a human membrane or brain cells.