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 | Nanotech 2007 Vol. 2
Technical Proceedings of the 2007 NSTI Nanotechnology Conference and Trade Show, Volume 2
Chapter 8: Bio Materials and Tissues |
| | Nano-Surface Behavior of Osteoblast Cell-Cultured Ti-30(Nb,Ta) with Low Elastic Modulus | | Authors: | H.C. Choe, Y.M. Ko and W. Brantley | | Affilation: | Chosun University, KR | | Pages: | 744 - 747 | | Keywords: | nano surface, osteoblast, cell culture, Ti-Nb, Ta Alloy | | Abstract: | Ti and Ti-alloys have good biocompatibility, appropriate mechanical properties and excellent corrosion resistance. However, the widely used Ti-6Al-4V is found to release toxic ions (Al and V) into the body, leading to undesirable long-term effects. Ti-6Al-4V has much higher elastic modulus (100 GPa) than cortical bone (20 GPa). Therefore, titanium alloys with low elastic modulus have been developed as biomaterials to minimize stress shielding. Objective: The electrochemical behavior of surface-modified and MC3T3-E1 cell-cultured Ti-30(Nb,Ta) alloys with low elastic modulus have been investigated using various electrochemical methods. Methods: Surfaces of test samples were treated as follows: 0.3 m polished; 25 m, 50 m and 125 m sandblasted. Specimen surfaces were cultured with MC3T3-E1 cells for 2 days. Average surface roughness (Ra) and morphology of specimens were determined using a surface profilometer, OM, and FE-SEM. Corrosion behavior was investigated using a potentiostat(EG&G PARSTAT 2273), and electrochemical impedance spectroscopy was performed (10 mHz to 100 kHz) in 0.9% NaCl solution at 36.5±1oC. Results: The microstructures of the Ti-30(Ta,Nb) alloys had a needle-like appearance. The Ra of polished Ti-30Ta and Ti-30Nb alloys was lower than that of the sandblasted Ti alloy. Cultured cells displayed round shapes. For polished alloy samples, cells were well-cultured on all surfaces compared to sandblasted alloy samples. In sandblasted and cell-cultured Ti-30(Nb,Ta) alloy, the pitting potential decreased and passive current density increased as Ra increased. Anodic polarization curves of cell-cultured Ti alloys showed unstable behavior in the passive region compared to non-cell-cultured alloys. From impedance tests of sandblasted and cell-cultured alloys, the polarization resistance decreased as Ra increased, whereas, Ra for cell-cultured Ti alloys increased compared to non-cell-cultured Ti alloys. Conclusions: The corrosion resistance of these alloys decreases as surface roughness increases. Cell-cultured surfaces show good corrosion resistance against chloride ion-like halides. | | ISBN: | 1-4200-6183-6 |
| Pages: | 838 |
| Hardcopy: | $199.99 |
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