Gish D.A., Nsiah F., McDermott M.T., Brett M.J.
University of Alberta, CA
Keywords: biosensor, glancing angle deposition, localized surface plasmon resonance, silver nanostructures
The localized surface plasmon resonance (LSPR) biosensing capability of 175 nm thick silver nanoparticle films produced by glancing angle deposition (GLAD) was evaluated. The extinction spectra of the films exhibited a peak around a wavelength of 369 nm which was observed to red-shift linearly with increasing refractive index of the surrounding medium. The films were functionalized with solutions of 11-amino-1-undecanethiol, hydrochloride and rabbit immunoglobulin G (IgG) to allow for the detection of anti-rabbit IgG binding. Binding of biomolecules to the nanoparticle surface increases the local refractive index and results in a red-shifting of the extinction peak. The wavelength shift at varying concentrations of anti-rabbit IgG was measured and fit to the Langmuir isotherm.
Journal: TechConnect Briefs
Volume: 2, Technical Proceedings of the 2007 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: May 20, 2007
Pages: 461 - 464
Industry sector: Sensors, MEMS, Electronics
Topics: Biomaterials, Chemical, Physical & Bio-Sensors
ISBN: 1-4200-6183-6