Petri B., Bootz A., Khalanski A., Hekmatara T., Müller R., Kreuter J., Gelperina S.
Moscow Medical Academy, RU
Keywords: brain tumour, doxorubicin, lipoproteins, nanoparticles
Polysorbate 80(Tween® 80)-coated poly(butyl cyanoacrylate) nanoparticles have been shown to enable the transport of doxorubicin (DOX) across the blood-brain barrier (BBB). This formulation produced a high antitumoral effect in an orthotopic model of the very aggressive rat glioblastoma 101/8. In the present study, the antitumoral effect of the poloxamer 188 (Pluronic® F 68)-coated DOX-loaded nanoparticles against glioblastoma 101/8 was tested and compared to earlier studies with polysorbate 80-coated nanoparticles. In addition, the protein adsorption pattern of DOX-loaded and polysorbate 80- or poloxamer 188 -coated poly(butyl cyanoacrylate) nanoparticles after incubation in rat plasma was investigated. These results show that the chemotherapeutical efficacy as well as plasma adsorption patterns of both surfactants were very similar, showing a high Apo A-I adsorption.. Thus efficacy of these formulations may be related to the high adsorption of ApoA-I, which is a ligand for the SR-BI. This is the first study that shows a significant correlation between the adsorption of ApoA-I on the nanoparticle surface and transport of a drug across the BBB.
Journal: TechConnect Briefs
Volume: 2, Technical Proceedings of the 2007 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: May 20, 2007
Pages: 386 - 389
Industry sector: Medical & Biotech
Topics: Biomaterials, Materials for Drug & Gene Delivery
ISBN: 1-4200-6183-6