Nanotech 2007 Vol. 2
Nanotech 2007 Vol. 2
Technical Proceedings of the 2007 NSTI Nanotechnology Conference and Trade Show, Volume 2

Biomarkers & Nanoparticles Chapter 4

Gold nanoshells aided optical imaging in vitro, in vivo and ex vivo

Authors: M. Lee, C. Loo, A.M. Gobin, J. West, N. Halas and R. Drezek

Affilation: Korea Electronics Technology Institute, Korea

Pages: 306 - 309

Keywords: nanoshells, OCT

Abstract:
Scattering-based optical imaging technologies such as Optical Coherence Tomography (OCT) and Reflectance Confocal Microscopy (RCM) offer a unique non-invasive approach to the detection, diagnosis, and monitoring of cancer. In this article, we describe the use of targeted NIR-tuned gold nanoshell for imaging in vitro, ex vivo and in vivo. Nanoshells are a new class of optically active nanoparticles with tunable plasmon resonances based on geometric construction. These particles can be easily tuned to absorb or scatter strongly within the wavelengths of 650-1300 nm, known as the near infrared region. This region is of significant biological importance providing a therapeutic window and imaging applications in tissue as the primary components of tissue, blood and water, do not have significant absorption coefficients in this range of wavelengths


ISBN: 1-4200-6183-6
Pages: 838
Hardcopy: $139.95

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