Authors: M.D. Bhavsar, S.B. Tiwari and M.M. Amiji
Affilation: Northeastern University, United States
Pages: 366 - 369
Keywords: nanoparticle-in-microsphere, factorial design, oral delivery system
The objective of the present study was to optimize the processing parameters for nanoparticles-in-microsphere hybrid system for oral delivery (NiMOS) and to mathematically relate the process parameters with the selected attribute (particle size) of the hybrid system. Gelatin nanoparticles were encapsulated in poly(epsilon caprolactone) micropshere and this system was optimized for particle size using a full 3^3 factorial design. Particles with size less than 10 micrometer were processed based on the results obtained from factorial design. These particles can be used for the oral delivery of macromolecules such as proteins and other therapeutics.