| |
 | Nanotech 2006 Vol. 2
Technical Proceedings of the 2006 NSTI Nanotechnology Conference and Trade Show, Volume 2
Chapter 5: Drug Delivery |
| | Nanoconjugates of poly(malic acid) with functional modules for drug delivery | | Authors: | J.Y. Ljubimova, M. Fujita, B.-S. Lee, N.M. Khazenzon, S. Wachsmann-Hogiu, D.L. Farkas, K.L. Black and E. Holler | | Affilation: | Cedars-Sinai Medical Center, US | | Pages: | 354 - 357 | | Keywords: | antisense oligonucleotides, antibodies, tissue targeting, fluorescence imaging, tumor angiogenesis | | Abstract: | Nanoconjugates of β-poly(L-malic acid) (PMLA) have been synthesized with modules active in drug delivery, drug release, blocking of tumor-affiliated mRNA by antisense oligonucleotides, penetration of blood and cellular barriers, tissue targeting, membrane permeation, fluorescence, and protection. PMLA of microbial origin is non-toxic, nonimmunogenic, biodegradable and highly suited as a scaffold for tailored nanoconjugate chemistry. The nanoconjugate of 550 kDa allowed fluorescence imaging of brain tumor and breast cancer implanted on mouse, targeted on the basis of tumor tissue-inherent enhanced permeability and retention (EPR) and antibody recognition. The nanoconjugates were designed to inhibit tumor growth by preventing angiogenesis. | | ISBN: | 0-9767985-7-3 |
| Pages: | 893 |
| Hardcopy: | $185.00 |
|
| Order: | Mail/Fax Form |
| Special: | 3 CD Set — 15% off with Free Shipping |
| Up | |
|
| nanoPRwire™ |
 |
| News Headlines |
 |
|
|
| |
| |
|
| | |
| |
|
|
