Papers:
Polysaccharide based Nanoparticles and Nanoporous matrices
We have successfully obtained good quality SPM images of the gel state of selected polysaccharides. The images reveal a surprisingly flat surface richly decorated with 30-50 nm deep pores. This type of insight we believe [...]
In vitro human model for tumor target screening in Cancer research
Mertsching H., Weimer M., Brunner H., Fraunhofer Institute of Interfacial Engineering and Biotechnology, DE
Monolayer and suspension cultures are still a highly artificial cellular environment for target screening and drug development. They have limited predictive value for target screening especially for nanomaterials. Target screening requires testsystems that mimic the [...]
Less Harmful Acidic Degradation of Poly(lactide-co-glycolide) Bone Tissue Engineering Scaffolds through Titania Nanoparticle Addition
In the last ten years, biodegradable aliphatic polyesters, such as poly(lactide-co-glycolide) acid (PLGA), have attracted increasing attention for their use as scaffold materials in bone tissue engineering because their degradation products can be removed by [...]
Wettability Engineering and Bioactivation of Hydroxyapatite Nanoceramics
The major trends in biotechnology and tissue engineering are development of materials with controlled surface substrates. One of the critical factors influencing adhesion of biocells is wettability properties of the biomimetic substrates. Hydrophilicity (hydrophobicity) of [...]
Nanoscale Analysis of Bone Mineral Crystals
Chen H., Robinson C., Shore R.C., Brookes S.J., Zhang J., Smith D.A., Clarkson B.H., Kirkham J., University of Michigan, US
The mineral component of both bones and teeth comprises of crystals of calcium hydroxyapatite. However, there are very few studies which have characterised and compared individual crystals from these mineralised tissues at the nanoscale. In [...]
Nano-Hydroxyapatite Coated Acetabular Cup Implant by Electrophoretic Deposition
Zhang H., Zhang Z., Krajewski J., Zhang H., Zhang Z., Xiao T.D., Reisner D., Inframat Corporation, US
A nanostructural hydroxyapatite (HA) coating was deposited to the porous Ti6Al4V hip cup implant using electrophoretic deposition (EPD) in order to improve the bonding strength between the implants and cells, fast healing, good resistance to [...]
Enzymatically Degradable Hydrogel Nanocomposite for Bone Regeneration
One approach to bone replacement involves the use of in-situ crosslinkable scaffolds for cell transplantation to promote tissue growth, nutrient diffusion, matrix production, and vascularization. Bone matrix is a composite material consisting of aqueous and [...]
On Chip Induced Phagocytosis for Improved Neuronal Cell Adhesion
Van Meerbergen B., Raemaekers T., Winters K., Braeken D., Bartic C., Engelborghs Y., Annaert W., Borghs G., IMEC, BE
Efficient integration of neuronal cells and electronic devices could result in hybrid bi-directional communication systems that would enable us to interact at fundamental level with biological structures and get insight in the mechanisms governing their [...]
Cluster assembled nanostructured TiO2 film mediates efficient and safe retroviral gene transduction in primary adult human melanocytes for ex-vivo gene therapy
Carbone R., Marangi I., Zanardi A., Lanfrancone L., Minucci S., Pelicci P.G., Giorgetti L., Clerici E., Bongiorno G., Piseri P., Milani P., European Institute of Oncology, IT
Primary human melanocytes represent the precursor cells to melanoma and also specific targets of inherited and acquired pigmentation disorders (1,3). The possibility to genetically manipulate these cells for biological studies or therapy has not been [...]
Qualitative Evaluation of the Response of Human Osteoblast Cells to Nanotopography Surfaces Based on Carbon Nanotubes
Firkowska I., Giannona S., Rojas-Chapana J., Giersig M., Center of Advanced European Studies and Research, DE
The organization of cells within an extracellular matrix is critical to promote appropriate cellular interactions and tissue function in vivo. The ability to design and create a nano-patterning on surfaces provides new capabilities for tissue [...]
Increased Osteoblast Adhesion on Nano-rough Anodized Titanium and CoCrMo
Titanium and cobalt-based alloys are two main groups of metallic materials widely used in orthopedic applications. One approach to improve biological properties of current titanium and CoCrMo implant is to mimic the nanostructures of natural [...]
Multicomponent Coatings Improve the Biocompatibility of Load-bearing Implants
Chissov V.I., Reshetov I.V., Frank G.A., Levashov E.A., Shtansky D.V., Filushin M.M., Efremov G.D., Sukharev S.S., P.A.Hertzen Moscow Research Oncological Institute, RU
New implants are studied in vivo under the conditions, when the replaced defect is located on the bone, which accomplishes motions with the large amplitude and with the large load.Three types of implants were placed [...]
Stem cell differentiation on nano-structured carbon surfaces
The research is based on the differentiation of stem cells on carbonnanofibers.
Study of Bioactive Films Using Natural Macromolecules
The control of interactions between living cells and modified surfaces is important for tissue engineering and may assist in the fabrication of bioactive coatings. Here we investigated the attachment of fibroblasts cells on bio-surfaces fabricated [...]
Nano-Structured Biodegradable Ceramics for the Treatment of Osteoporosis
There are a number of applications requiring bone-building agents. For example, osteoporosis is a disease resulting in weak bone. However, no current effective prevention and treatment methods exist for osteoporosis. For these reasons, in this [...]
Transport of Multiple Enzymes through Semipermeable Membrane and Effect of Surfactants
Trigo C., Leung S.W., Bhushan A., Daniels C.K., Lai J.C.K., Idaho State University, College of Engineering, US
Surfactants are known to influence functions of many proteins in membranes, cells and tissues. Because most studies to elucidate the effects of surfactants on membrane-bound proteins and cells employed heterogeneous or complex systems, it is [...]
3D Microfabricated Bioreactors
We present here an innovative three dimensional microfabrication technology that will serve as a vehicle to enable vascularized bioreactors for in vitro tissue culture. The core of our microfabrication technology is a high-resolution projection micro [...]
DNA/Cellulose hybrid nanomaterials
One potential advantage of nanotechnology is the ability to engineer bottom-up hierarchical assembly of nanoparticles into functional macroscale materials and devices. The most promising mechanism for accomplishing this is self-assembly. In this project, an advanced [...]
Improvement of Polycaprolactone Nanofibers Topographies: Testing the Influence in Osteoblastic Proliferation
The nanofiber technology of present interest focuses on the electrospinning technique, which conveniently allows the preparation of fibrous materials with very fine diameters ranging from submicron to several nanometers. With the ability to form nanofibrous [...]
In vitro testing of the penetration and permeation of nanomaterials on a artificial human skin model
Weimer M., Mertsching H., Brunner H., Fraunhofer Institute of Interfacial Engineering and Biotechnology, DE
We established a tissue engineered 3D human skin model. This interactive 3D-co-cultre consists of living human primary keratinocytes with a well-differentiated stratum corneum and an epidermal layer. The dermal layer is composed of a Type [...]
Patterned nanofiber meshes for biomedical applications
The typical end-product of the electrospinning process is a randomly aligned fibre mesh or membrane. This is a result of the electric field generated between the drop of polymer solution at the needle and the [...]
Increasing the Thermal Stability of Self-Assembling DNA Nanostructures by Incorporation of isoG/isoC Base Pairs
Self-assembling DNA nanostructures are currently being developed for a variety of applications in nanofabrication and molecular computing. For many uses, these nanostructures would benefit from increased thermal stability. However, increasing the lengths of sticky-ends that [...]
Journal: TechConnect Briefs
Volume: 2, Technical Proceedings of the 2006 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: May 7, 2006
Industry sector: Medical & Biotech
Topic: Biomaterials
ISBN: 0-9767985-7-3