Fernández-Pacheco R., Ibarra M.R., Valdivia J.G., Marquina C., Serrate D., Romero M.S., Gutiérrez M., Arbiol J.
Institute of Nanoscience of Aragon, ES
Keywords: local therapy, magnetic implants, magnetic nanoparticles
Bioferrofluid obtained using iron coated nanoparticles are promising candidates for magnetic drug delivery. The carbon cages made the particles biocompatibles and provide a suport for drug adsortion. We propose a new method in which gold plated permanent magnets are implanted close to the tumor by using endoscopic techniques in the affected organ. The bioferrofluid charged with the chemiotherapic is injected and the particles are attracted to the magnet and desorption of the drug take place at the tumoral región. This method has advantages over the aplication of external fields being more effective and also avoiding the need to be at the place of the big external magnets. We report the procedures to obtain the bioferrofluids and in-vitro experiments. In vivo experiments performed on rabits revealed the reliability of this method.
Journal: TechConnect Briefs
Volume: 1, Technical Proceedings of the 2005 NSTI Nanotechnology Conference and Trade Show, Volume 1
Published: May 8, 2005
Pages: 144 - 147
Industry sector: Medical & Biotech
Topics: Biomaterials, Materials for Drug & Gene Delivery
ISBN: 0-9767985-0-6